Fig. 3

Drug sensitivity in primary GSCs across different drug classes and molecular targets. The figure displays drug class, the drug sensitivity in GSC cultures, and average (± SD) Spearman’s coefficient (ρ) from correlation matrices for drug categories that were represented with ≥3 drugs for the specific molecular target (n = 47 drugs in the figure, all drug sensitivity data in Additional file 3). Correlation matrices demonstrated that the sensitivity to a drug within a category was strongly associated with sensitivity to all other drugs within that drug category, demonstrating biological consistency and individual uniqueness in GSC cultures. Highlighted in red and blue are the tumors found with the highest and lowest sensitivity within the specified category, respectively