TY - JOUR AU - Rønning, P. A. AU - Helseth, E. AU - Meling, T. R. AU - Johannesen, T. B. PY - 2012 DA - 2012// TI - A population-based study on the effect of temozolomide in the treatment of glioblastoma multiforme JO - Neuro-Oncology VL - 14 UR - https://doi.org/10.1093/neuonc/nos153 DO - 10.1093/neuonc/nos153 ID - Rønning2012 ER - TY - JOUR AU - Touat, M. AU - Idbaih, A. AU - Sanson, M. AU - Ligon, K. L. PY - 2017 DA - 2017// TI - Glioblastoma targeted therapy: updated approaches from recent biological insights JO - Ann Oncol VL - 28 UR - https://doi.org/10.1093/annonc/mdx106 DO - 10.1093/annonc/mdx106 ID - Touat2017 ER - TY - JOUR AU - Brennan, C. W. AU - Verhaak, R. G. W. AU - McKenna, A. AU - Campos, B. AU - Noushmehr, H. AU - Salama, S. R. PY - 2013 DA - 2013// TI - The somatic genomic landscape of glioblastoma JO - Cell. VL - 155 UR - https://doi.org/10.1016/j.cell.2013.09.034 DO - 10.1016/j.cell.2013.09.034 ID - Brennan2013 ER - TY - JOUR AU - Verhaak, R. G. W. AU - Hoadley, K. A. AU - Purdom, E. AU - Wang, V. AU - Qi, Y. AU - Wilkerson, M. D. PY - 2010 DA - 2010// TI - Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 JO - Cancer Cell VL - 17 UR - https://doi.org/10.1016/j.ccr.2009.12.020 DO - 10.1016/j.ccr.2009.12.020 ID - Verhaak2010 ER - TY - JOUR AU - Sottoriva, A. AU - Spiteri, I. AU - Piccirillo, S. G. M. AU - Touloumis, A. AU - Collins, V. P. AU - Marioni, J. C. PY - 2013 DA - 2013// TI - Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics JO - Proc Natl Acad Sci U S A VL - 110 UR - https://doi.org/10.1073/pnas.1219747110 DO - 10.1073/pnas.1219747110 ID - Sottoriva2013 ER - TY - JOUR AU - Patel, A. P. AU - Tirosh, I. AU - Trombetta, J. J. AU - Shalek, A. K. AU - Gillespie, S. M. AU - Wakimoto, H. PY - 2014 DA - 2014// TI - Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma JO - Science. VL - 344 UR - https://doi.org/10.1126/science.1254257 DO - 10.1126/science.1254257 ID - Patel2014 ER - TY - JOUR AU - Chinot, O. L. AU - Wick, W. AU - Mason, W. AU - Henriksson, R. AU - Saran, F. AU - Nishikawa, R. PY - 2014 DA - 2014// TI - Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma JO - N Engl J Med VL - 370 UR - https://doi.org/10.1056/NEJMoa1308345 DO - 10.1056/NEJMoa1308345 ID - Chinot2014 ER - TY - JOUR AU - Westphal, M. AU - Heese, O. AU - Steinbach, J. P. AU - Schnell, O. AU - Schackert, G. AU - Mehdorn, M. PY - 2015 DA - 2015// TI - A randomised, open label phase III trial with nimotuzumab, an anti-epidermal growth factor receptor monoclonal antibody in the treatment of newly diagnosed adult glioblastoma JO - Eur J Cancer VL - 51 UR - https://doi.org/10.1016/j.ejca.2014.12.019 DO - 10.1016/j.ejca.2014.12.019 ID - Westphal2015 ER - TY - JOUR AU - Stupp, R. AU - Taillibert, S. AU - Kanner, A. AU - Read, W. AU - Steinberg, D. M. AU - Lhermitte, B. PY - 2017 DA - 2017// TI - Effect of tumor-treating fields plus maintenance Temozolomide vs maintenance Temozolomide alone on survival in patients with glioblastoma JO - JAMA. VL - 318 UR - https://doi.org/10.1001/jama.2017.18718 DO - 10.1001/jama.2017.18718 ID - Stupp2017 ER - TY - JOUR AU - Witt Hamer, P. C. PY - 2010 DA - 2010// TI - Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies JO - Neuro-Oncology VL - 12 UR - https://doi.org/10.1093/neuonc/nop068 DO - 10.1093/neuonc/nop068 ID - Witt Hamer2010 ER - TY - JOUR AU - Sepúlveda-Sánchez, J. M. AU - Vaz, M. Á. AU - Balana, C. AU - Gil-Gil, M. AU - Reynés, G. AU - Gallego, Ó. PY - 2017 DA - 2017// TI - Phase II trial of dacomitinib, a pan-human EGFR tyrosine kinase inhibitor, in recurrent glioblastoma patients with EGFR amplification JO - Neuro-Oncology VL - 19 UR - https://doi.org/10.1093/neuonc/nox105 DO - 10.1093/neuonc/nox105 ID - Sepúlveda-Sánchez2017 ER - TY - JOUR AU - Lan, X. AU - Jörg, D. J. AU - Cavalli, F. M. G. AU - Richards, L. M. AU - Nguyen, L. V. AU - Vanner, R. J. PY - 2017 DA - 2017// TI - Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy JO - Nature. VL - 549 UR - https://doi.org/10.1038/nature23666 DO - 10.1038/nature23666 ID - Lan2017 ER - TY - JOUR AU - Lee, J. AU - Kotliarova, S. AU - Kotliarov, Y. AU - Li, A. AU - Su, Q. AU - Donin, N. M. PY - 2006 DA - 2006// TI - Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines JO - Cancer Cell VL - 9 UR - https://doi.org/10.1016/j.ccr.2006.03.030 DO - 10.1016/j.ccr.2006.03.030 ID - Lee2006 ER - TY - JOUR AU - Vik-Mo, E. O. AU - Sandberg, C. AU - Olstorn, H. AU - Varghese, M. AU - Brandal, P. AU - Ramm-Pettersen, J. PY - 2010 DA - 2010// TI - Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions JO - Neuro-Oncology VL - 12 UR - https://doi.org/10.1093/neuonc/noq102 DO - 10.1093/neuonc/noq102 ID - Vik-Mo2010 ER - TY - JOUR AU - Davis, B. AU - Shen, Y. AU - Poon, C. C. AU - Luchman, H. A. AU - Stechishin, O. D. AU - Pontifex, C. S. PY - 2016 DA - 2016// TI - Comparative genomic and genetic analysis of glioblastoma-derived brain tumor-initiating cells and their parent tumors JO - Neuro-Oncology VL - 18 UR - https://doi.org/10.1093/neuonc/nov143 DO - 10.1093/neuonc/nov143 ID - Davis2016 ER - TY - JOUR AU - Rosenberg, S. AU - Verreault, M. AU - Schmitt, C. AU - Guegan, J. AU - Guehennec, J. AU - Levasseur, C. PY - 2017 DA - 2017// TI - Multi-omics analysis of primary glioblastoma cell lines shows recapitulation of pivotal molecular features of parental tumors JO - Neuro-Oncology VL - 19 ID - Rosenberg2017 ER - TY - JOUR AU - Piccirillo, S. G. M. AU - Colman, S. AU - Potter, N. E. AU - Delft, F. W. AU - Lillis, S. AU - Carnicer, M. -. J. PY - 2015 DA - 2015// TI - Genetic and functional diversity of propagating cells in glioblastoma JO - Stem Cell Reports VL - 4 UR - https://doi.org/10.1016/j.stemcr.2014.11.003 DO - 10.1016/j.stemcr.2014.11.003 ID - Piccirillo2015 ER - TY - JOUR AU - Visnyei, K. AU - Onodera, H. AU - Damoiseaux, R. AU - Saigusa, K. AU - Petrosyan, S. AU - Vries, D. PY - 2011 DA - 2011// TI - A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells JO - Mol Cancer Ther VL - 10 UR - https://doi.org/10.1158/1535-7163.MCT-11-0268 DO - 10.1158/1535-7163.MCT-11-0268 ID - Visnyei2011 ER - TY - JOUR AU - Hothi, P. AU - Martins, T. J. AU - Chen, L. AU - Deleyrolle, L. AU - Yoon, J. -. G. AU - Reynolds, B. PY - 2012 DA - 2012// TI - High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells JO - Oncotarget. VL - 3 UR - https://doi.org/10.18632/oncotarget.707 DO - 10.18632/oncotarget.707 ID - Hothi2012 ER - TY - JOUR AU - Lun, X. AU - Wells, J. C. AU - Grinshtein, N. AU - King, J. C. AU - Hao, X. AU - Dang, N. -. H. PY - 2016 DA - 2016// TI - Disulfiram when combined with copper enhances the therapeutic effects of Temozolomide for the treatment of glioblastoma JO - Clin Cancer Res VL - 22 UR - https://doi.org/10.1158/1078-0432.CCR-15-1798 DO - 10.1158/1078-0432.CCR-15-1798 ID - Lun2016 ER - TY - JOUR AU - KK-H, Y. AU - Taylor, J. T. AU - Pathmanaban, O. N. AU - Youshani, A. S. AU - Beyit, D. AU - Dutko-Gwozdz, J. PY - 2018 DA - 2018// TI - High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma JO - PLoS One VL - 13 UR - https://doi.org/10.1371/journal.pone.0193694 DO - 10.1371/journal.pone.0193694 ID - KK-H2018 ER - TY - JOUR AU - Pemovska, T. AU - Kontro, M. AU - Yadav, B. AU - Edgren, H. AU - Eldfors, S. AU - Szwajda, A. PY - 2013 DA - 2013// TI - Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia JO - Cancer Discovery VL - 3 UR - https://doi.org/10.1158/2159-8290.CD-13-0350 DO - 10.1158/2159-8290.CD-13-0350 ID - Pemovska2013 ER - TY - JOUR AU - Yadav, B. AU - Pemovska, T. AU - Szwajda, A. AU - Kulesskiy, E. AU - Kontro, M. AU - Karjalainen, R. PY - 2014 DA - 2014// TI - Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies JO - Sci Rep VL - 4 UR - https://doi.org/10.1038/srep05193 DO - 10.1038/srep05193 ID - Yadav2014 ER - TY - JOUR AU - Mao, P. AU - Joshi, K. AU - Li, J. AU - Kim, S. -. H. AU - Li, P. AU - Santana-Santos, L. PY - 2013 DA - 2013// TI - Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3 JO - Proc Natl Acad Sci U S A VL - 110 UR - https://doi.org/10.1073/pnas.1221478110 DO - 10.1073/pnas.1221478110 ID - Mao2013 ER - TY - JOUR AU - Phillips, H. S. AU - Kharbanda, S. AU - Chen, R. AU - Forrest, W. F. AU - Soriano, R. H. AU - Wu, T. D. PY - 2006 DA - 2006// TI - Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis JO - Cancer Cell VL - 9 UR - https://doi.org/10.1016/j.ccr.2006.02.019 DO - 10.1016/j.ccr.2006.02.019 ID - Phillips2006 ER - TY - JOUR AU - Varghese, M. AU - Olstorn, H. AU - Sandberg, C. AU - Vik-Mo, E. O. AU - Noordhuis, P. AU - Nistér, M. PY - 2008 DA - 2008// TI - A comparison between stem cells from the adult human brain and from brain tumors JO - Neurosurgery. VL - 63 UR - https://doi.org/10.1227/01.NEU.0000335792.85142.B0 DO - 10.1227/01.NEU.0000335792.85142.B0 ID - Varghese2008 ER - TY - JOUR AU - Karajannis, M. A. AU - Legault, G. AU - Fisher, M. J. AU - Milla, S. S. AU - Cohen, K. J. AU - Wisoff, J. H. PY - 2014 DA - 2014// TI - Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas JO - Neuro-Oncology VL - 16 UR - https://doi.org/10.1093/neuonc/nou059 DO - 10.1093/neuonc/nou059 ID - Karajannis2014 ER - TY - JOUR AU - Weller, M. AU - Butowski, N. AU - Tran, D. D. AU - Recht, L. D. AU - Lim, M. AU - Hirte, H. PY - 2017 DA - 2017// TI - Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial JO - Lancet Oncol VL - 18 UR - https://doi.org/10.1016/S1470-2045(17)30517-X DO - 10.1016/S1470-2045(17)30517-X ID - Weller2017 ER - TY - JOUR AU - Tourneau, C. AU - Delord, J. -. P. AU - Gonçalves, A. AU - Gavoille, C. AU - Dubot, C. AU - Isambert, N. PY - 2015 DA - 2015// TI - Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial JO - Lancet Oncol. VL - 16 UR - https://doi.org/10.1016/S1470-2045(15)00188-6 DO - 10.1016/S1470-2045(15)00188-6 ID - Tourneau2015 ER - TY - JOUR AU - Letai, A. PY - 2017 DA - 2017// TI - Functional precision cancer medicine—moving beyond pure genomics JO - Nature. VL - 23 ID - Letai2017 ER - TY - JOUR AU - Iwadate, Y. AU - Fujimoto, S. AU - Namba, H. AU - Yamaura, A. PY - 2003 DA - 2003// TI - Promising survival for patients with glioblastoma multiforme treated with individualised chemotherapy based on in vitro drug sensitivity testing JO - Br J Cancer VL - 89 UR - https://doi.org/10.1038/sj.bjc.6601376 DO - 10.1038/sj.bjc.6601376 ID - Iwadate2003 ER - TY - JOUR AU - Quartararo, C. E. AU - Reznik, E. AU - deCarvalho, A. C. AU - Mikkelsen, T. AU - Stockwell, B. R. PY - 2015 DA - 2015// TI - High-throughput screening of patient-derived cultures reveals potential for precision medicine in glioblastoma JO - ACS Med Chem Lett VL - 6 UR - https://doi.org/10.1021/acsmedchemlett.5b00128 DO - 10.1021/acsmedchemlett.5b00128 ID - Quartararo2015 ER - TY - JOUR AU - Meyer, M. AU - Reimand, J. AU - Lan, X. AU - Head, R. AU - Zhu, X. AU - Kushida, M. PY - 2015 DA - 2015// TI - Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity JO - Proc Natl Acad Sci U S A VL - 112 UR - https://doi.org/10.1073/pnas.1320611111 DO - 10.1073/pnas.1320611111 ID - Meyer2015 ER - TY - JOUR AU - Segerman, A. AU - Niklasson, M. AU - Haglund, C. AU - Bergström, T. AU - Jarvius, M. AU - Xie, Y. PY - 2016 DA - 2016// TI - Clonal variation in drug and radiation response among glioma-initiating cells is linked to proneural- mesenchymal transition JO - Cell Rep VL - 17 UR - https://doi.org/10.1016/j.celrep.2016.11.056 DO - 10.1016/j.celrep.2016.11.056 ID - Segerman2016 ER - TY - JOUR AU - Muhic, A. AU - Poulsen, H. S. AU - Sorensen, M. AU - Grunnet, K. AU - Lassen, U. PY - 2013 DA - 2013// TI - Phase II open-label study of nintedanib in patients with recurrent glioblastoma multiforme JO - J Neuro-Oncol VL - 111 UR - https://doi.org/10.1007/s11060-012-1009-y DO - 10.1007/s11060-012-1009-y ID - Muhic2013 ER - TY - JOUR AU - Chang, S. M. AU - Kuhn, J. G. AU - Robins, H. I. AU - Schold, S. C. AU - Spence, A. M. AU - Berger, M. S. PY - 2001 DA - 2001// TI - A phase II study of paclitaxel in patients with recurrent malignant glioma using different doses depending upon the concomitant use of anticonvulsants: a north American brain tumor consortium report JO - Cancer. VL - 91 UR - https://doi.org/3.0.CO;2-9 DO - 3.0.CO;2-9 ID - Chang2001 ER - TY - JOUR AU - Wick, W. AU - Gorlia, T. AU - Bady, P. AU - Platten, M. AU - Bent, M. J. AU - Taphoorn, M. J. B. PY - 2016 DA - 2016// TI - Phase II study of radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in patients with newly diagnosed glioblastoma without MGMT promoter Hypermethylation (EORTC 26082) JO - Clin Cancer Res VL - 22 UR - https://doi.org/10.1158/1078-0432.CCR-15-3153 DO - 10.1158/1078-0432.CCR-15-3153 ID - Wick2016 ER - TY - JOUR AU - Lesimple, T. AU - Riffaud, L. AU - Frappaz, D. AU - Ben Hassel, M. AU - Gédouin, D. AU - Bay, J. -. O. PY - 2009 DA - 2009// TI - Topotecan in combination with radiotherapy in unresectable glioblastoma: a phase 2 study JO - J Neuro-Oncol VL - 93 UR - https://doi.org/10.1007/s11060-008-9774-3 DO - 10.1007/s11060-008-9774-3 ID - Lesimple2009 ER - TY - JOUR AU - Blough, M. D. AU - Westgate, M. R. AU - Beauchamp, D. AU - Kelly, J. J. AU - Stechishin, O. AU - Ramirez, A. L. PY - 2010 DA - 2010// TI - Sensitivity to temozolomide in brain tumor initiating cells JO - Neuro-Oncology VL - 12 UR - https://doi.org/10.1093/neuonc/noq032 DO - 10.1093/neuonc/noq032 ID - Blough2010 ER - TY - STD TI - Kierulf-Vieira KS, Sandberg CJ, Grieg Z, Günther C-C, Langmoen IA, Vik-Mo EO. Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation. Exp. Cell Res. 2015. ID - ref40 ER - TY - JOUR AU - Skaga, E. AU - Skaga, I. Ø. AU - Grieg, Z. AU - Sandberg, C. J. AU - Langmoen, I. A. AU - Vik-Mo, E. O. PY - 2019 DA - 2019// TI - The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy JO - J Cancer Res Clin Oncol VL - 58 ID - Skaga2019 ER - TY - JOUR AU - Li, A. AU - Walling, J. AU - Kotliarov, Y. AU - Center, A. AU - Steed, M. E. AU - Ahn, S. J. PY - 2008 DA - 2008// TI - Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas JO - Mol Cancer Res VL - 6 UR - https://doi.org/10.1158/1541-7786.MCR-07-0280 DO - 10.1158/1541-7786.MCR-07-0280 ID - Li2008 ER - TY - JOUR AU - Vik-Mo, E. O. AU - Nyakas, M. AU - Mikkelsen, B. V. AU - Moe, M. C. AU - Due-Tønnesen, P. AU - Suso, E. M. I. PY - 2013 DA - 2013// TI - Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma JO - Cancer Immunol Immunother Heidelberg VL - 62 UR - https://doi.org/10.1007/s00262-013-1453-3 DO - 10.1007/s00262-013-1453-3 ID - Vik-Mo2013 ER - TY - JOUR AU - Sandberg, C. J. AU - Altschuler, G. AU - Jeong, J. AU - Strømme, K. K. AU - Stangeland, B. AU - Murrell, W. PY - 2013 DA - 2013// TI - Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome JO - Exp Cell Res VL - 319 UR - https://doi.org/10.1016/j.yexcr.2013.06.004 DO - 10.1016/j.yexcr.2013.06.004 ID - Sandberg2013 ER - TY - JOUR AU - Laks, D. R. AU - Masterman-Smith, M. AU - Visnyei, K. AU - Angenieux, B. AU - Orozco, N. M. AU - Foran, I. PY - 2009 DA - 2009// TI - Neurosphere formation is an independent predictor of clinical outcome in malignant glioma JO - Stem Cells VL - 27 UR - https://doi.org/10.1002/stem.15 DO - 10.1002/stem.15 ID - Laks2009 ER - TY - JOUR AU - D'Alessandris, Q. G. AU - Biffoni, M. AU - Martini, M. AU - Runci, D. AU - Buccarelli, M. AU - Cenci, T. PY - 2017 DA - 2017// TI - The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response JO - Neuro-Oncology VL - 19 UR - https://doi.org/10.1093/neuonc/now304 DO - 10.1093/neuonc/now304 ID - D'Alessandris2017 ER -