Can pattern and depth of invasion predict lymph node relapse and prognosis in tongue squamous cell carcinoma

BMC Cancer

Table 2 Univariate and multivariate analyses about parameters relevant to lymph node relapse

Items	All patients (n)	With lymph node relapse	Without lymph node relapse	Univariate analysis		Multi-variate analysis
Items	All patients (n)	With lymph node relapse	Without lymph node relapse	OR (95%CI)	P value*	OR (95%CI)	P value#
Gender
Male	75	24	51	Reference		Reference
Female	66	12	54	0.47 (0.21–1.04)	0.063	0.64 (0.15–2.69)	0.541
Age (years old)
< 55	59	14	45	Reference		Reference
≥ 55	82	22	60	1.18 (0.54–2.56)	0.677	1.23 (0.45–3.34)	0.683
Growth mode of invasive front
Crumb	79	8	71	Reference		Reference
Trabes	62	28	34	7.31 (3.01–17.72)	0.001	5.03 (1.52–16.68)	0.008
Depth of invasion
< 4 mm	43	1	42	Reference		Reference
≥ 4 mm	98	35	63	23.33 (3.08–176.91)	0.002	12.23 (1.31–113.90)	0.028
Pathological differentiation
Well	48	7	41	Reference		Reference
Moderate/poor	93	29	64	2.65 (1.06–6.62)	0.036	0.76 (0.22–2.62)	0.667
Neurovascular invasion
No	123	25	98	Reference		Reference
Yes	18	11	7	6.16 (2.17–17.51)	0.001	2.20 (0.61–7.97)	0.232
Location
Anterior	14	1	13	Reference		Reference
Middle	103	25	78	4.17 (0.52–33.46)	0.179	5.05 (0.52–49.44)	0.164
Back	24	10	14	9.29 (1.04–82.96)	0.046	5.74 (0.50–66.52)	0.162
T stage
T1	60	8	52	Reference		Reference
T2	81	28	53	3.43 (1.43–8.23)	0.006	1.42 (0.46–4.35)	0.543
Smoking
No	82	15	67	Reference		Reference
Yes	59	21	38	2.47 (1.14–5.35)	0.022	0.05 (0.00–2.00)	0.11
Drinking
No	89	15	74	Reference		Reference
Yes	52	21	31	3.34 (1.53–7.32)	0.003	33.62 (0.97–1169.50)	0.052
Treatment
Observation	72	15	57	Reference		Reference
Neck dissection	69	21	48	1.66 (0.77–3.58)	0.193	1.15 (0.41–3.26)	0.794

OR odds ratio, CI confidence interval; P*: uni-variate regression analysis; P#: multi-variate regression analysis. Note: entries in boldface means: P < 0.05

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