Predictors of mammographic density among women with a strong family history of breast cancer

Moran, Olivia; Eisen, Andrea; Demsky, Rochelle; Blackmore, Kristina; Knight, Julia A.; Panchal, Seema; Ginsburg, Ophira; Zbuk, Kevin; Yaffe, Martin; Metcalfe, Kelly A.; Narod, Steven A.; Kotsopoulos, Joanne

doi:10.1186/s12885-019-5855-2

BMC Cancer

Table 5 Adjusted mean mammographic density measures according to anthropometric and lifestyle factors among postmenopausal women

From: Predictors of mammographic density among women with a strong family history of breast cancer

		Postmenopausal women (n = 59)
		Percent Density (%)				Dense Area (cm²)				Non-Dense Area (cm²)
	n	Mean¹ PD	95% CI¹	P ¹	n	Mean¹ DA	95% CI¹	P ¹	n	Mean¹ NDA	95% CI¹	P ¹
Weight
<77.0 kg	43	14.7	9.3-21.5		40	19.4	12.4-27.8		40	117.4	88.0-151.0
≥77.0 kg	16	8.7	4.2-14.8	0.04	15	18.7	11.3-28.1	0.88	15	184.8	143.4-231.4	0.0007
Height
<170 cm	47	13.4	8.8-19.1		43	20.3	13.8-28.2		43	137.3	111.7-165.6
≥170 cm	12	15.4	8.2-24.7	0.56	12	18.3	9.4-30.0	0.63	12	98.3	66.9-135.7	0.01
TWA
<43.0 MET-hrs/week	49	13.7	8.7-19.7		45	18.9	12.1-27.2		45	123.5	96.3-154.1
≥43.0 MET-hrs/week	10	12.7	6.4-21.0	0.76	10	19.5	10.4-31.6	0.88	10	148.7	108.4-195.3	0.16
MVPA
<27.0 METs/week	45	12.4	7.6-18.3		41	17.0	10.5-25.1		41	128.8	99.4-162.1
≥27.0 METs/week	14	15.8	9.5-23.6	0.25	14	23.1	14.3-33.9	0.14	14	126.5	93.3-164.7	0.88
Smoking status
Never	30	10.8	6.5-16.1	ref	29	16.4	10.3-23.9	ref	29	138.6	110.4-170.1	ref
Former	22	19.5	13.2-27.0	0.003	20	26.9	18.1-37.4	0.01	20	108.4	81.1-139.8	0.04
Current smoker	7	10.8	4.5-19.9	0.99	6	14	5.4-26.4	0.62	6	134.0	89.4-187.7	0.84
Age at first use
<16 years	14	20.5	9.7-35.3		12	32.0	15.9-53.6		12	91.2	47.1-149.8
≥16 years	15	26.2	14.8-40.8	0.35	14	36.9	21.9-55.8	0.58	14	111.3	68.8-163.9	0.42
Packs smoked
<3 packs per week	8	18.8	7.9-34.3		7	35.0	17.0-59.4		7	126.2	70.7-197.7
≥3 packs per week	21	25.1	14.7-38.3	0.26	19	35.2	21.3-52.7	0.98	19	100.8	63.2-147	0.28
Duration of use
<14 years	13	24.3	12.1-40.8		11	37.5	20.1-60.3		11	121.7	71.0-186.1
≥14 years	16	23.8	13.3-37.3	0.91	15	34.5	20.5-52.0	0.70	15	98.9	61.1-145.8	0.30
Alcohol use
Never	5	16.8	7.6-29.6	ref	4	23.2	9.8-42.3	ref	4	102.6	59.0-158.3	ref
Former	8	16.9	8.1-28.9	0.99	8	22.9	11.0-39.1	0.98	8	108.5	68.6-157.5	0.83
Current user	46	14.1	9.4 19.8	0.58	43	20.4	13.7-28.4	0.70	43	128.7	103.1-157.1	0.30
Age at first use
<18 years	20	12.1	6.9-18.8		17	17.7	10.2-27.2		17	138.9	106.0-176.2
≥18 years	34	15.1	9.7-21.7	0.29	34	22.3	14.8-31.5	0.26	34	122.6	95.4-153.2	0.30
Drinks consumed
<2 drinks per week	35	13.4	8.3-19.7		33	19.1	12.2-27.6		33	120.4	93.8-150.3
≥2 drinks per week	19	14.9	8.8-22.5	0.62	18	23.4	14.6-34.3	0.32	18	143.5	110.2-181.2	0.14

¹Adjusted least-square means, 95% confidence intervals, and P-values are from analyses using square root-transformed mammographic density measures. The adjusted least-square means and 95% confidence intervals were back-transformed
All models were adjusted for age (continuous) and BMI (continuous) at the time of mammogram, parity (continuous), and mammogram modality (digital image, film scanned by study team, film scanned by imaging centre). The height and weight models were mutually adjusted for each other (continuous) instead of BMI. The physical activity models were additionally adjusted for smoking status (never, former, current). The smoking models were additionally adjusted for the number of alcoholic drinks consumed per week (continuous). The alcohol models were additionally adjusted for smoking status (never/ever). TWA, total weekly activity. MVPA, moderate-to-vigorous physical activity. METs, Metabolic Equivalent of Task

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