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Table 4 Adjusted mean mammographic density measures according to anthropometric and lifestyle factors among premenopausal women

From: Predictors of mammographic density among women with a strong family history of breast cancer

  

Premenopausal women (n = 97)

 

Percent Density (%)

 

Dense Area (cm2)

 

Non-Dense Area (cm2)

n

Mean1 PD

95% CI1

P 1

n

Mean1 DA

95% CI1

P 1

n

Mean1 NDA

95% CI1

P 1

Weight

 <77.0 kg

71

33.2

23.7-44.2

 

64

35.3

22.4-51.1

 

64

73.2

47.6-104.4

 

 ≥77.0 kg

26

17.6

9.4-28.4

0.0006

24

31.9

17.1-51.4

0.59

24

165.2

115.9-223.2

<0.0001

Height

 <170 cm

69

27.0

18.3-37.5

 

63

32.4

19.2-48.9

 

63

97.7

66.5-135.0

 

 ≥170 cm

28

33.2

23.1-45.1

0.18

25

37.0

23.1-54.3

0.47

25

78.6

51.3-111.8

0.16

TWA

 <43.0 MET-hrs/week

69

26.4

17.1-37.8

 

62

30.6

17.4-47.5

 

63

94.6

63.0-132.6

 

 ≥43.0 MET-hrs/week

28

24.1

14.6-36.0

0.58

26

29.8

15.7-48.2

0.88

25

93.9

59.8-135.6

0.96

MVPA

 <27.0 METs/week

72

26.1

17.1-37.0

 

64

30.2

17.3-46.6

 

64

93.9

63.0-131.0

 

 ≥27.0 METs/week

25

23.6

13.6-36.3

0.55

24

30.7

16.0-50.1

0.93

24

95.6

60.2-139.3

0.90

Smoking status

 Never

64

28.9

20.3-39.1

ref

58

33.5

20.8-49.3

ref

58

89.5

61.4-122.9

ref

 Former

26

29.3

19.3-41.5

0.93

23

36.2

21.5-54.8

0.68

23

102.4

68.7-142.9

0.36

 Current smoker

7

18.1

6.8-34.9

0.14

7

19.7

5.2-43.5

0.15

7

87.7

42.3-149.3

0.94

Age at first use

 <16 years

10

19.8

7.3-38.3

 

10

30.0

12.3-55.4

 

10

130.4

78.6-195.3

 

 ≥16 years

23

28.8

14.0-49.0

0.15

20

46.7

25.0-75.1

0.07

20

127.9

79.8-187.4

0.90

Packs smoked

 <3 packs/week

20

29.2

14.4-49.3

 

18

48.1

27.5-74.5

 

18

125.5

78.4-183.6

 

 ≥3 packs/week

13

19.5

7.3-37.6

0.12

12

25.5

10.0-48.2

0.01

12

135.9

81.7-203.8

0.64

Duration of use

 <14 years

16

32.2

17.4-51.3

 

14

53.1

32.0-79.5

 

14

126.0

77.5-186.3

 

 ≥14 years

17

15.8

5.6-31.2

0.01

16

25.3

11.0-45.5

0.002

16

132.7

80.6-197.8

0.76

Alcohol use

 Never

10

29.7

17.4-45.1

ref

9

38.1

18.9-63.8

ref

9

103.3

61.0-156.6

ref

 Former

15

30.5

18.1-46.2

0.91

15

32.8

16.4-54.7

0.64

15

79.7

45.8-122.9

0.31

 Current user

72

27.9

19.1-38.3

0.78

64

33.8

21.0-49.7

0.66

64

96.0

67.3-129.7

0.73

Age at first use

 <18 years

29

21.5

11.8-34.2

 

27

28.9

15.2-47.0

 

27

118.8

78.4-167.6

 

 ≥18 years

58

27.5

17.7-39.3

0.14

52

34.3

21.0-51.0

0.34

52

90.6

60.1-127.4

0.05

Drinks consumed

 <2 drinks/week

60

25.2

15.4-37.4

 

57

33.0

19.1-50.7

 

57

92.5

59.0-133.4

 

 ≥2 drinks/week

27

27.7

17.0-41.1

0.58

22

33.2

19.0-51.3

0.98

22

101.1

65.3-144.6

0.58

  1. 1Adjusted least-square means, 95% confidence intervals, and P-values are from analyses using square root-transformed mammographic density measures. The adjusted least-square means and 95% confidence intervals were back-transformed
  2. All models were adjusted for age (continuous) and BMI (continuous) at the time of mammogram, parity (continuous), and mammogram modality (digital image, film scanned by study team, film scanned by imaging centre). The height and weight models were mutually adjusted for each other (continuous) instead of BMI. The physical activity models were additionally adjusted for smoking status (never, former, current). The smoking models were additionally adjusted for the number of alcoholic drinks consumed per week (continuous). The alcohol models were additionally adjusted for smoking status (never/ever). TWA, total weekly activity. MVPA, moderate-to-vigorous physical activity. METs, Metabolic Equivalent of Task