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Fig. 5 | BMC Cancer

Fig. 5

From: Expression patterns of small numbers of transcripts from functionally-related pathways predict survival in multiple cancers

Fig. 5

Whole transcriptome analysis further refines the predictive power of t-SNE profiling. a. Unsupervised hierarchical clustering of whole transcriptome profiles from 177 pancreatic adenocarcinomas (22). Three major groups were identified (Dendro 1, Dendro 2, and Dendro 3) and are indicated by the green, blue and red horizontal bars, respectively, at the topv of the heat map. Within each Dendro group, individual tumors, previously classified by t-SNE for their expression patterns of purine biosynthesis family transcripts (Clusters 1–3: Additional file 1: Figure S5) are indicated by the red, blue and yellow-colored bars, respectively, at the bottom of the heat map. b. Kaplan-Meier survival curves of patients from each of the Dendro groups in A. c. Tumors from Purine Biosynthesis Pathway t-SNE Cluster 3 (unfavorable survival) were further divided according to the dendrogram group with which they associated and Kaplan-Meier curves were again generated. d. Similar to (c), patients from Purine Biosynthesis Pathway t-SNE Cluster 1 (favorable survival) were also grouped according to the Dendro group with which they associated. See Additional file 1: Figures S39-S41 for additional examples of this type of analysis

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