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Table 4 Adverse events due to intra-arterial injection

From: Intra-arterial chemotherapy as primary or secondary treatment for infants diagnosed with advanced retinoblastoma before 3 months of age

Ocular adverse events

No. of eyes (%)

Severe

 Cellulitis-like severe orbital inflammation

None

 Diffuse chorioretinal atrophy

None

Mild

 Erythematous eyelid

1 (2.4%)

 Fundus hemorrhage

5 (11.9%)

Systemic adverse events

No. of patients (%)

Severe

 Cerebral infarction

None

 Myelosuppression

3 (7.7%)

 Sepsis

None

Mild

 Intraoperative bradycardia due to the vagal reflex

None

 Intraoperative bronchospasm

None

 Transient vomiting and hair loss

1 (2.6%)

 Transient pancytopenia

1 (2.6%)

  1. Note: a Some patients had more than one adverse event