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Table 2 Descriptive characteristics of CRC patients according to molecular markers in the DACHS cohort

From: External validation of molecular subtype classifications of colorectal cancer based on microsatellite instability, CIMP, BRAF and KRAS

Variable n (%) Overall n = 1915 MSS n = 1698 (89%) MSI n = 217 (11%) p-val BRAF wt n = 1759 (92%) BRAF mut n = 156 (8%) p-val KRAS wt n = 1293 (68%) KRAS mut n = 622 (32%) p-val CIMP-low n = 1572 (82%) CIMP-high n = 343 (18%) p-val
Age groups
 <  65 629 (33) 566 (33) 63 (29) < 0.001 598 (34) 31 (20) < 0.001 437 (34) 192 (31) 0.425 551 (35) 78 (23) < 0.001
 65–74 654 (34) 596 (35) 58 (27)   609 (35) 45 (29)   433 (33) 221 (36)   542 (35) 112 (33)  
 >  75 632 (33) 536 (32) 96 (44)   552 (31) 80 (51)   423 (33) 209 (34)   479 (31) 153 (45)  
Sex
 Female 808 (42) 690 (41) 118 (54) < 0.001 705 (40) 103 (66) < 0.001 547 (42) 261 (42) 0.887 625 (40) 183 (53) < 0.001
 Male 1107 (58) 1008 (59) 99 (46)   1054 (60) 53 (34)   746 (58) 361 (58)   947 (60) 160 (47)  
Location
 Proximal colon 684 (36) 501 (30) 183 (85) < 0.001 555 (32) 129 (83) < 0.001 441 (35) 243 (40) 0.100 464 (30) 220 (64) < 0.001
 Distal colon 497 (26) 476 (28) 21 (10)   483 (28) 14 (9)   344 (27) 153 (25)   441 (28) 56 (16)  
 Rectum 714 (38) 703 (42) 11 (5)   702 (40) 12 (8)   495 (39) 219 (36)   648 (42) 66 (19)  
TNM stage
 Stage I 355 (19) 321 (19) 34 (16) < 0.001 336 (19) 19 (12) 0.068 239 (19) 116 (19) 0.276 293 (19) 62 (18) 0.015
 Stage II 644 (34) 525 (31) 119 (55)   580 (33) 64 (41)   453 (35) 191 (31)   504 (32) 140 (41)  
 Stage III 652 (34) 594 (35) 58 (27)   603 (34) 49 (31)   428 (33) 224 (36)   553 (35) 99 (29)  
 Stage IV 264 (14) 258 (15) 6 (3)   240 (14) 24 (15)   173 (13) 91 (15)   222 (14) 42 (12)  
Chemotherapy
 No 1045 (55) 893 (53) 152 (71) < 0.001 948 (54) 97 (63) 0.036 714 (56) 331 (53) 0.343 829 (53) 216 (63) < 0.001
 Yes 857 (45) 794 (47) 63 (29)   800 (46) 57 (37)   568 (44) 289 (47)   731 (47) 126 (37)  
  1. MSS microsatellite stability, MSI microsatellite instability, BRAF wt BRAF wild type, BRAF mut BRAF mutated, KRAS wt KRAS wild-type, KRAS mut KRAS mutated
  2. p-values from Chi-square or Fischer’s exact tests for the association of the two variables