Table 2 Descriptive characteristics of CRC patients according to molecular markers in the DACHS cohort
Variable n (%) | Overall n = 1915 | MSS n = 1698 (89%) | MSI n = 217 (11%) | p-val | BRAF wt n = 1759 (92%) | BRAF mut n = 156 (8%) | p-val | KRAS wt n = 1293 (68%) | KRAS mut n = 622 (32%) | p-val | CIMP-low n = 1572 (82%) | CIMP-high n = 343 (18%) | p-val |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age groups | |||||||||||||
< 65 | 629 (33) | 566 (33) | 63 (29) | < 0.001 | 598 (34) | 31 (20) | < 0.001 | 437 (34) | 192 (31) | 0.425 | 551 (35) | 78 (23) | < 0.001 |
65–74 | 654 (34) | 596 (35) | 58 (27) | 609 (35) | 45 (29) | 433 (33) | 221 (36) | 542 (35) | 112 (33) | ||||
> 75 | 632 (33) | 536 (32) | 96 (44) | 552 (31) | 80 (51) | 423 (33) | 209 (34) | 479 (31) | 153 (45) | ||||
Sex | |||||||||||||
Female | 808 (42) | 690 (41) | 118 (54) | < 0.001 | 705 (40) | 103 (66) | < 0.001 | 547 (42) | 261 (42) | 0.887 | 625 (40) | 183 (53) | < 0.001 |
Male | 1107 (58) | 1008 (59) | 99 (46) | 1054 (60) | 53 (34) | 746 (58) | 361 (58) | 947 (60) | 160 (47) | ||||
Location | |||||||||||||
Proximal colon | 684 (36) | 501 (30) | 183 (85) | < 0.001 | 555 (32) | 129 (83) | < 0.001 | 441 (35) | 243 (40) | 0.100 | 464 (30) | 220 (64) | < 0.001 |
Distal colon | 497 (26) | 476 (28) | 21 (10) | 483 (28) | 14 (9) | 344 (27) | 153 (25) | 441 (28) | 56 (16) | ||||
Rectum | 714 (38) | 703 (42) | 11 (5) | 702 (40) | 12 (8) | 495 (39) | 219 (36) | 648 (42) | 66 (19) | ||||
TNM stage | |||||||||||||
Stage I | 355 (19) | 321 (19) | 34 (16) | < 0.001 | 336 (19) | 19 (12) | 0.068 | 239 (19) | 116 (19) | 0.276 | 293 (19) | 62 (18) | 0.015 |
Stage II | 644 (34) | 525 (31) | 119 (55) | 580 (33) | 64 (41) | 453 (35) | 191 (31) | 504 (32) | 140 (41) | ||||
Stage III | 652 (34) | 594 (35) | 58 (27) | 603 (34) | 49 (31) | 428 (33) | 224 (36) | 553 (35) | 99 (29) | ||||
Stage IV | 264 (14) | 258 (15) | 6 (3) | 240 (14) | 24 (15) | 173 (13) | 91 (15) | 222 (14) | 42 (12) | ||||
Chemotherapy | |||||||||||||
No | 1045 (55) | 893 (53) | 152 (71) | < 0.001 | 948 (54) | 97 (63) | 0.036 | 714 (56) | 331 (53) | 0.343 | 829 (53) | 216 (63) | < 0.001 |
Yes | 857 (45) | 794 (47) | 63 (29) | 800 (46) | 57 (37) | 568 (44) | 289 (47) | 731 (47) | 126 (37) | ||||