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Fig. 4 | BMC Cancer

Fig. 4

From: Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents

Fig. 4

Localization of PSMA in dorsal root ganglia. (a): Transverse section through a CT image of the spinal column, between cervical vertebrae C6 and C7. (b): Overlay of PET and CT, showing tracer accumulation in the intervertebral foramina, where dorsal root ganglia are localized. (c): Overview of a dorsal root ganglion section, stained with H&E and anti-PSMA, corresponding to the radioactivity accumulation in the intervertebral foramen. (d): Zoomed fragment of (c), showing PSMA-immunostaining in satellite glial cells (arrowheads). (e): Control staining without primary antibody. Abbreviations: N: neuron; IF: intervertebral foramen; VC: vertebral canal. Scale bars: 5 mm in (a) + (b), 25 μm in (c) and 5 μm in (d) + (e)

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