Fig. 3
From: Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents
Cervical ganglia in healthy rats for validation of PSMA ligands. (a): Biodistribution of [18F]DCFPyL, horizontal plane. (b): Blocking experiment with [18F]DCFPyL + 2-PMPA (23 mg/kg). (c): Biodistribution of [Al18F]PSMA-11; high accumulation in bones reflected substantial defluorination. (d): Biodistribution of [68Ga]PSMA-11. (e): Quantitative analysis of SCG tracer uptake, SCG signal-to-noise ratio, liver and bone (sternum) uptake. See also Table 1. (f): Similarity of tracer uptake in left and right SCG, shown for [18F]DCFPyL (n = 6, black bars) and [68Ga]PSMA-11 (n = 3, gray bars). (g): Four rats with two PSMA-PET measurements on different days, demonstrating stability of the ganglionic PSMA pattern. The second measurement in rat 1 was with [68Ga]PSMA-11, all others with 18F-labeled PSMA tracers (*). Abbreviations: C3–C7: cervical vertebrae 3–7; DRG: dorsal root ganglia; HH: humeral head (bone); SCG: superior cervical ganglion; SG: salivary gland; SJ: shoulder joint (cartilage); SNR: signal-to-noise ratio; STG: stellate ganglion. Scale bar: 1 cm