Fig. 3

miR-23b and miR-27b knockout cell orthotopic tumor xenograft growth. a. Tumor xenograft growth curve, n = 6 mice per group, Two-way ANOVA, * p < 0.05, **** p < 0.0001. b. Survival analysis of empty vector, miR-23b, and miR-27b, knockout xenograft mice fed a standard diet, n = 6 mice per group. Survival curves were compared using the Log-rank (Mantel-Cox) test in GraphPad Prism. Representative images (c) and quantification (d) of Ki-67 immunohistochemistry staining of xenograft tumor tissue, black bar = 100 μm; n = 9 per group, *p < 0.05, ** p < 0.01, Student’s t-test