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Table 4 Hazard Ratios for death. Brute and adjusted for age. Stage IV of the disease and mutated

From: Impact of genetic mutations and nutritional status on the survival of patients with colorectal cancer

Nutrition indicators

HR brute (CI95%)

p

HR adjusted

(CI 95%) - Age

p

HR adjusted

(CI 95%) - Stage IV of the disease

p

HR adjusted

(CI 95%) – Mutated KRAS gene

p

BMI (kg/m2)

 Normal

1.0

1.0

1.0

1.0

 Undernourished

2.66 (0.88; 8.02)

0.081

2.32 (0.74; 7.23)

0.147

3.02 (0.97; 9.40)

0.056

1.83 (0.49; 6.89)

0.366

 Overweight / Obesity

0.31 (0.06; 1.53)

0.153

0.36 (0.07; 1.84)

0.225

0.38 (0.07; 1.93)

0.247

0.30 (0.05; 1.60)

0.160

Nutritional risk screening

 Without nutritional risk

1.0

1.0

1.0

1.0

 Nutritional rsk

8.77 (1.14; 67.1)

0.036

7.30 (0.88; 59.9)

0.064

8.16 (1.04; 63.7)

0.045

7.24 (0.91; 57.3)

0.060

PG-SGA

 Well nourished

1.0

1.0

1.0

1.0

 Moderetely / Severely malnourished

3.95 (1.11; 14.0)

0.033

3.10 (0.82; 11.7)

0.095

3.66 (1.02; 13.1)

0.046

4.28 (0.91; 20.1)

0.065

Phase angle

  > 5o

1.0

1.0

1.0

1.0

  < 5o

3.79 (1.10; 13.1)

0.035

2.85 (0.73; 11.1)

0.130

7.15 (1.71; 29.8)

0.007

3.07 (0.66; 14.1)

0.151

Visceral adipose tisse

  > 163.8 cm2 - male

1.0

1.0

1.0

1.0

  > 80.1 cm2 – female

        

  < 163.8 cm2 – male

3.43 (1.03; 11.4)

0.044

4.08 (1.22; 13.6)

0.022

2.98 (0.88; 10.0)

0.077

4.94 (1.19; 20.5)

0.028

  < 80.1 cm2 – female

        

Sarcopenia

 Without sarcopenic

1.0

1.0

1.0

1.0

 Sarcopenic

3.95 (1.06; 14.6)

0.040

4.08 (1.22; 13.6)

0.092

3.46 (0.92; 13.0)

0.066

3.12 (0.74; 13.1)

0.121

  1. HR Hazard ratio