Table 2 Subanalysis of stage-by-stage of Cox proportional hazards models analysis for identifying the prognosis factors for metastasis between metachronous metastasis CRC patients and non-met CRC patients after last follow-up
From: Serum chitinase activity prognosticates metastasis of colorectal cancer
Characteristics | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | p Value | HR | 95% CI | p Value | |
All CRC patients with Stage I – III at first visit (Cox proportional hazards models) | ||||||
Age (≥median vs. <median) median = 62 y | 1.395 | 0.789–2.466 | 0.251 | |||
Sex (male vs. female) | 1.313 | 0.739–2.334 | 0.351 | |||
T stage (T3/T4 vs. T1/T2) | 2.474 | 0.890–6.879 | 0.073 | |||
N stage (N1/N2 vs. N0) | 3.686 | 1.954–6.951 | < 0.0001 | 3.133 | 1.590–6.174 | 0.001 |
CEA (≥5 vs. < 5) | 1.276 | 0.718–2.267 | 0.405 | |||
Tumor location (Colon vs. Rectum) | 1.165 | 0.663–2.046 | 0.596 | |||
Histological type (Mucus adenocarcinoma vs. Adenocarcinoma) | 1.812 | 0.769–4.274 | 0.168 | |||
Tumor size (≥Median vs. <Median) | 1.084 | 0.617–1.904 | 0.778 | |||
Schistosomiasis history (Yes vs. No) | 1.131 | 0.352–3.638 | 0.836 | |||
Treatment (Surgery vs. Surgery+ Postoperative chemotherapy) | 2.562 | 1.241–5.290 | 0.011 | 0.605 | 0.279–1.312 | 0.203 |
Chitinase enzyme activity (≥Cut-off vs. <Cut-off) | 2.703 | 1.487–4.912 | 0.001 | 2.785 | 1.532–5.064 | 0.001 |
CRC patients with Stage I and II at first visit (Cox proportional hazards models) a | ||||||
Age (≥median vs. <median) Median = 63 y | 2.157 | 0.704–6.609 | 0.168 | |||
Sex (male vs. female) | 0.952 | 0.320–2.833 | 0.930 | |||
T stage (T3/T4 vs. T1/T2) | 0.811 | 0.250–2.636 | 0.727 | |||
CEA (≥5 vs. < 5) | 2.334 | 0.782–6.968 | 0.118 | |||
Tumor location (Colon vs. Rectum) | 1.115 | 0.374–3.320 | 0.845 | |||
Tumor size (≥Median vs. <Median) | 1.058 | 0.356–3.149 | 0.919 | |||
Schistosomiasis history (Yes vs. No) | 1.151 | 0.150–8.857 | 0.892 | |||
Treatment (Surgery vs. Surgery+ Postoperative chemotherapy) | 0.371 | 0.114–1.206 | 0.086 | |||
Chitinase enzyme activity (≥Cut-off vs. <Cut-off) | 7.101 | 1.585–31.814 | 0.010 | 7.101 | 1.585–31.814 | 0.010 |
CRC patients with Stage III at first visit (Cox proportional hazards models) | ||||||
Age (≥median vs. <median) median = 63 y | 1.219 | 0.631–2.352 | 0.556 | |||
Sex (male vs. female) | 1.316 | 0.666–2.600 | 0.429 | |||
CEA (≥5 vs. < 5) | 0.962 | 0.492–1.881 | 0.910 | |||
Tumor location (Colon vs. Rectum) | 1.119 | 0.579–2.164 | 0.738 | |||
Histological type (Mucus adenocarcinoma vs. Adenocarcinoma) | 1.518 | 0.630–3.655 | 0.352 | |||
Tumor size (≥Median vs. <Median) | 1.071 | 0.554–2.069 | 0.838 | |||
Schistosomiasis history (Yes vs. No) | 1.453 | 0.349–6.054 | 0.608 | |||
Treatment (Surgery vs. Surgery+ Postoperative chemotherapy) | 0.845 | 0.328–2.179 | 0.727 | |||
Chitinase enzyme activity (≥Cut-off vs. <Cut-off) | 2.100 | 1.078–4.093 | 0.03 | 2.100 | 1.078–4.093 | 0.03 |