Table 1 Univariate and Multivariable Cox regression analysis of CRC patients’ metastasis probability in training, testing and total sets for identifying the prognosis factors for metastasis between metachronous metastasis CRC patients and non-met CRC patients after last follow-up

 Age (>median vs. ≤ median)

0.786 (0.249–2.477)

0.680

1.671 (0.851–3.282)

0.136

1.395 (0.789–2.466)

0.251

 Sex (male vs. female)

1.776 (0.535–5.889)

0.348

1.181 (0.612–2.278)

0.019

1.313 (0.739–2.334)

0.351

 T stage (T3/T4 vs. T1/T2)

3.125 (0.403–24.251)

0.276

2.216 (0.680–7.215)

0.187

2.474 (0.890–6.879)

0.073

 N stage (N1/N2 vs. N0)

6.677 (1.462–30.493)

0.014

3.153 (1.557–6.385)

0.001

3.686 (1.954–6.951)

0.000

 CEA (≥5 vs. < 5)

1.560 (0.503–4.838)

0.442

1.158 (0.589–2.275)

0.67

1.276 (0.718–2.267)

0.405

 Tumor location (Colon vs. Rectum)

1.006 (0.324–3.128)

0.992

1.217 (0.635–2.334)

0.554

1.165 (0.663–2.046)

0.596

 Histological type (Mucus adenocarcinoma vs. Adenocarcinoma)

2.609 (0.571–11.923)

0.216

1.55 (0.546–4.397)

0.41

1.812 (0.769–4.274)

0.168

 Tumor size (≥Median vs. <Median)

1.089 (0.345–3.436)

0.884

1.103 (0.578–2.107)

0.766

1.084 (0.617–1.904)

0.778

 Schistosomiasis history (Yes vs. No)

1.991 (0.254–15.608)

0.512

0.920 (0.221–3.826)

0.909

1.131 (0.352–3.638)

0.836

 Treatment (Surgery vs. Surgery+ Postoperative chemotherapy)

3.588 (0.786–16.375)

0.099

2.334 (1.025–5.313)

0.044

2.562 (1.241–5.290)

0.011

 Chitinase enzyme activity (≥Cut-off vs. <Cut-off)

5.670 (1.535–20.948)

0.009

2.094 (1.065–4.115)

0.032

2.703 (1.487–4.912)

0.001

 N stage (N1/N2 vs. N0)

6.413 (1.403–29.311)

0.017

3.229 (1.594–6.54)

0.001

3.726 (1.976–7.027)

0.000

 Chitinase enzyme activity (≥Cut-off vs. <Cut-off)

5.443 (1.472–20.122)

0.011

2.168 (1.103–4.261)

0.025

2.739 (1.507–4.978)

0.001