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Table 3 SLNB reduction rates using the ANN model to predict disease-free axilla. Possible SLNB reduction rate corresponding to cut-offs at maximum negative predictive value, false negative rate 5 and 10%, respectively

From: Artificial neural network models to predict nodal status in clinically node-negative breast cancer

 

N0 vs. N+ n = 800

Cut-off Max NPV 0.95

TP

TN

FP

FN

No.

283

57

457

3

SLNB Reduction Rate

(TN + FN) / (TP + TN + FP + FN) = 7.50%

False Negative Rate

FN / (TP + FN) = 1.05%

Cut-off

NPV 0.90

TP

TN

FP

FN

No.

272

128

386

14

SLNB Reduction Rate

(TN + FN) / (TP + TN + FP + FN) = 17.75%

False Negative Rate

FN / (TP + FN) = 5%

Cut-off

NPV 0.87

TP

TN

FP

FN

No.

258

190

324

28

SLNB Reduction Rate

(TN + FN) / (TP + TN + FP + FN) = 27.25%

False Negative Rate

FN / (TP + FN) = 10%

  1. Abbreviations: N0 Lymph node negative, N+ Any lymph node metastasis, SLNB Sentinel lymph node biopsy, Max NPV Maximum negative predictive value, TP True positive, TN True negative, FP False positive, FN False negative