Table 1 Patient and tumor characteristics
From: Artificial neural network models to predict nodal status in clinically node-negative breast cancer
All (n = 800) | N0 (n = 514) | N1 (n = 232) | N2 (n = 54) | p value | |
|---|---|---|---|---|---|
Agea, years | 64 (24–92) | 64 (33–92) | 63 (24–92) | 62 (26–85) | 0.039b |
Missing | 0 | 0 | 0 | 0 | |
BMIa, kg/m2 | 25 (16–49) | 26 (16–44) | 26 (16–46) | 26 (20–49) | 0.569b |
Missing | 41 | 24 | 13 | 4 | |
Menopausal status | 0.011c | ||||
Premenopausal | 130 (17) | 70 (14) | 48 (22) | 12 (24) | |
Postmenopausal | 628 (83) | 414 (86) | 175 (78) | 39 (76) | |
Missing | 42 | 30 | 9 | 3 | |
Mode of detection | < 0.001c | ||||
Mammographic screening | 457 (57) | 321 (63) | 113 (49) | 23 (43) | |
Symptomatic presentation | 343 (43) | 193 (38) | 119 (51) | 31 (57) | |
Missing | 0 | 0 | 0 | 0 | |
Bilateral cancer | 0.255c | ||||
Absent | 770 (96) | 499 (97) | 222 (96) | 49 (91) | |
Present | 30 (4) | 15 (3) | 10 (4) | 5 (9) | |
Missing | 0 | 0 | 0 | 0 | |
Multifocality | < 0.001c | ||||
Absent | 610 (77) | 418 (82) | 161 (71) | 31 (61) | |
Present | 179 (23) | 92 (18) | 67 (29) | 20 (39) | |
Missing | 11 | 4 | 4 | 3 | |
Tumor site, quadrants of breast | 0.170d | ||||
Central C501 | 22 (3) | 14 (3) | 6 (3) | 2 (4) | |
Upper inner C502 | 108 (14) | 78 (15) | 25 (11) | 5 (9) | |
Lower inner C503 | 46 (6) | 32 (6) | 12 (5) | 2 (4) | |
Upper outer C504 | 266 (33) | 165 (32) | 86 (37) | 15 (28) | |
Lower outer C505 | 84 (11) | 43 (8) | 31 (13) | 10 (19) | |
Overlapping lesions: 3, 6, 9, 12 o’clock | 274 (34) | 182 (35) | 72 (31) | 20 (37) | |
Missing | 0 | 0 | 0 | 0 | |
Tumor sizea, mm | 15 (0.5–90) | 13 (0.5–70) | 17 (0.9–90) | 23 (6–70) | < 0.001b |
Missing | 1 | 0 | 1 | 0 | |
Histological type | 800 | 514 | 232 | 54 | 0.010 e |
Ductal | 640 (80) | 408 (79) | 195 (84) | 37 (69) | |
Lobular | 101 (13) | 60 (12) | 27 (12) | 14 (26) | |
Other | 59 (7) | 46 (9) | 10 (4) | 3 (6) | |
Missing | 0 | 0 | 0 | 0 | |
Histological grade | 0.003c | ||||
I | 197 (25) | 142 (28) | 48 (21) | 7 (13) | |
II | 366 (46) | 231 (46) | 106 (46) | 29 (54) | |
III | 229 (29) | 134 (26) | 77 (33) | 18 (33) | |
Missing | 8 | 7 | 1 | 0 | |
Vascular invasion | < 0.001c | ||||
Absent | 545 (85) | 401 (94) | 124 (72) | 20 (37) | |
Present | 94 (15) | 28 (7) | 48 (28) | 18 (33) | |
Missing | 161 | 85 | 60 | 16 | |
ER status | 0.020 c | ||||
Positive | 729 (91) | 459 (90) | 218 (94) | 52 (96) | |
Negative | 69 (9) | 53 (10) | 14 (6) | 2 (4) | |
Missing | 2 | 2 | 0 | 0 | |
PR status | 0.075c | ||||
Positive | 673 (84) | 421 (82) | 206 (89) | 46 (85) | |
Negative | 125 (16) | 91 (18) | 26 (11) | 8 (15) | |
Missing | 2 | 2 | 0 | 0 | |
HER2 status | 0.208c | ||||
Positive | 86 (12) | 51 (11) | 27 (13) | 15 (16) | |
Negative | 647 (88) | 422 (89) | 184 (87) | 41 (84) | |
Missing | 67 | 41 | 21 | 5 | |
Ki-67 a, % | 15 (0–94) | 14 (0–94) | 17 (1–81) | 20 (3–76) | 0.001b |
Missing | 48 | 29 | 16 | 3 |