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Table 3 Serum ITIH4 intensity of patients in subgroup analyses in terms of clinicopathological characteristics

From: Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study

Subgroup

NASH group

HCC with NAFLD group

p value

Patients without diabetes

4935 ± 903 (n = 35)

12,759 ± 1090 (n = 24)

<  0.0001

Patients without hypertension

4764 ± 1022 (n = 32)

13,228 ± 1022 (n = 32)

< 0.0001

Patients without obesity

5685 ± 1605 (n = 14)

13,772 ± 1115 (n = 29)

0.0002

Patients with Child-Pugh score: 5 or 6

5274 ± 917 (n = 40)

13,247 ± 804 (n = 52)

<  0.0001

Patients with F0–2 fibrosis a

4809 ± 791 (n = 35)

14,111 ± 780 (n = 36)

<  0.0001

  1. The serum ITIH4 intensity was compared between NASH and HCC with NAFLD groups
  2. Obesity was defined as a body mass index > 25
  3. Data are expressed as the mean ± standard deviation
  4. a Liver fibrosis was classified according to the METAVIR scoring system [15]