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Fig. 6 | BMC Cancer

Fig. 6

From: Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study

Fig. 6

Validation for serum expression of ITIH4 in patients. a Serum ITIH4 intensity in the simple steatosis (SS), NASH, HCC with NAFLD, and virus-related HCC groups from western blotting quantified by densitometry. SS group: n = 40, NASH group: n = 40, HCC with NAFLD group: n = 55, virus-related HCC group: n = 35. Not significant: N.S. b The probability of overall survival in NAFLD with HCC patients according to serum ITIH4 intensity. The 55 patients in the HCC with NAFLD group were divided into low ITIH4 and high ITIH4 groups. The low ITIH4 and high ITIH4 groups were defined as serum ITIH4 intensity < 14,000 and serum ITIH4 intensity ≥14,000, respectively. Overall survival (OS) was defined as the period from the day of hepatectomy for HCC until the day of death caused by HCC or liver failure. For patients who survived, the date of the last follow-up was set as March 31, 2017. Cumulative 5-year overall survival rates of patients in the low ITIH4 and high ITIH4 groups were 95.0 and 72.5%, respectively (P = 0.0353: Log-rank, P = 0.0222: Wilcoxon)

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