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Fig. 2 | BMC Cancer

Fig. 2

From: Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study

Fig. 2

Histological features of liver tumors in the NAFLD group. (a) Macroscopic view of the liver in the NAFLD group. All animals in the NAFLD group developed multiple liver tumors at 60 weeks. Encapsulated tumor nodules with various sizes were observed in the liver. (b) Histological features of tumor lesions with hematoxylin and eosin staining. Tumor lesions compressed the surrounding liver parenchyma and exhibited fatty changes (a: × 20). Cellular atypia with large nuclei, small cells, and trabecular structures were observed in the tumor lesions (b: × 200). (c) Immunohistochemistry for well-differentiated HCC markers in tumor lesions. Glutamine synthetase showed diffuse cytoplasmic staining (a: × 200). Glypican-3 showed faint staining (b: × 200). Heat-shock-protein 70 showed strongly diffuse nucleo-cytoplasmic staining, not only in the tumor lesions but also in the non-tumor lesions (c: × 200). Arginase-1 showed focal nucleo-cytoplasmic staining (d: × 200)

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