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Fig. 4 | BMC Cancer

Fig. 4

From: Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression

Fig. 4

Combination treatment of BEZ235 and cisplatin inhibited EMT and decreased CSC marker expression. a The protein expressions of EMT markers in EOC-cis cells after treatment with BEZ235 (½ IC50), cisplatin (½ IC50), or in combination for 48 h were detected by western blot. β-actin was used as a loading control. Combination treatment of BEZ235 and cisplatin obviously reversed EMT in EOC-cis cells. b The protein expressions of CSC markers in EOC-cis cells after treatment with BEZ235 (½ IC50), cisplatin (½ IC50), or in combination for 48 h were detected by western blot. β-actin was used as a loading control. Combination treatment of BEZ235 and cisplatin markedly inhibited CSC marker expression in EOC-cis cells

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BMC Cancer

ISSN: 1471-2407

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