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Fig. 1 | BMC Cancer

Fig. 1

From: Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression

Fig. 1

EOC-cis cell lines showed enhanced resistance to cisplatin and enhanced metastatic potential. a Cells were treated with different concentrations of cisplatin for 48 h and cell viability was tested using cell proliferation assay. EOC-cis cells showed significant resistance to cisplatin. b The invasion ability of cells within 48 h was detected using Matrigel invasion assay. Representative images for EOC cell invasion and migration were photogrphed at 200 x magnification. The invasive potential of EOC-cis cell lines was significantly increased as compared to parental cell lines. c The migration ability of cells within 96 h was detected by wound-healing assay. Typical images were obtained at 40x amplification at 0 h, 48 h, and 96 h and the percentage of wound closure area in 96 h was compared. A2780-cis and IGROV1-cis had a higher wound closure rate than the corresponding parental cells. All data were expressed as mean ± SD. **P < 0.01 and ***P < 0.001 versus parental cells (n = 3)

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