Table 1 Univariate and multivariate analyses (Cox regression) for overall survival in AML patients
Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age > 60 years | 2.7201 | 1.5917 to 4.6484 | < 0.0001* | 2.0425 | 1.2585 to 3.3148 | 0.0038* |
WBC > 100 k μ/L | 1.0529 | 0.6026 to 1.8399 | 0.8534 | – | – | – |
Favorable cytogenetics | 0.4552 | 0.2905 to 0.7133 | 0.0051* | 0.4579 | 0.2315 to 0.9058 | 0.0248* |
NPM1+/ FLT3-ITD- | 0.5674 | 0.3346 to 0.9625 | 0.0839 | 0.2972 | 0.1421 to 0.6216 | 0.0013* |
FLT3-TKD | 1.1062 | 0.5419 to 2.2580 | 0.7722 | – | – | – |
CEBPα double mutation | 0.3093 | 0.1839 to 0.5201 | 0.0030* | 0.3893 | 0.1585 to 0.9561 | 0.0396* |
PTPN11 mutation | 1.2426 | 0.5008 to 3.0836 | 0.6042 | – | – | – |
KRAS mutation | 1.6638 | 0.6351 to 4.3587 | 0.1885 | – | – | – |
MLL/PTD | 3.5868 | 1.0660 to 12.0688 | 0.0001* | 2.3662 | 1.0555 to 5.3047 | 0.0365* |
KIT mutation | 1.0609 | 0.4827 to 2.3319 | 0.8797 | – | – | – |
RUNX1 mutation | 2.2459 | 1.1285 to 4.4697 | 0.0013* | 1.2736 | 0.6998 to 2.3179 | 0.4285 |
WT1 mutation | 1.4062 | 0.7398 to 2.6728 | 0.2326 | – | – | – |
ASXL1 mutation | 0.8468 | 0.3932 to 1.8236 | 0.6921 | – | – | – |
IDH1 mutation | 0.5760 | 0.2364 to 1.4033 | 0.3395 | – | – | – |
IDH2 mutation | 0.9412 | 0.5109 to 1.7341 | 0.8492 | – | – | – |
TET2 mutation | 1.1970 | 0.6549 to 2.1879 | 0.5309 | – | – | – |
TP53 mutation | 4.3752 | 0.5761 to 33.2257 | 0.0015* | 3.1834 | 1.0992 to 9.2198 | 0.0328* |
DNMT3A mutation | 1.3679 | 0.8133 to 2.3004 | 0.1908 | – | – | – |
HOXB-AS3 expression | 2.3003 | 1.5530 to 3.4072 | <  0.0001* | 1.6401 | 0.9727 to 2.7654 | 0.0634 |