TY - JOUR AU - Kiener, Mirjam AU - Chen, Lanpeng AU - Krebs, Markus AU - Grosjean, Joël AU - Klima, Irena AU - Kalogirou, Charis AU - Riedmiller, Hubertus AU - Kneitz, Burkhard AU - Thalmann, George N. AU - Snaar-Jagalska, Ewa AU - Spahn, Martin AU - Kruithof-de Julio, Marianna AU - Zoni, Eugenio PY - 2019 DA - 2019/06/25 TI - miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo JO - BMC Cancer SP - 627 VL - 19 IS - 1 AB - Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with gene expression regulatory function, has been reported in all types of epithelial and haematological cancers. In particular, miR-221-5p alterations have been reported in PCa. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-019-5819-6 DO - 10.1186/s12885-019-5819-6 ID - Kiener2019 ER -