Table 2 Univariable and multivariable COX regression models for predicting cancer specific survival of bladder cancer
From: Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms
Variables | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age (< 65 yr. as reference) | ||||||
  ≥ 65 yr | 0.79 | 0.48–1.29 | 0.34 |  |  |  |
Gender (female as reference) | ||||||
 Male | 1.07 | 0.63–1.80 | 0.81 |  |  |  |
Pathological stage (T1 as reference) | ||||||
 T2 | 2.22 | 1.13–4.36 | 0.02 | 1.67 | 0.83–3.37 | 0.15 |
 T3 | 4.88 | 2.49–9.56 | < 0.01 | 3.32 | 1.62–6.80 | < 0.01 |
 T4 | 22.45 | 8.09–62.30 | < 0.01 | 16.70 | 5.85–47.69 | < 0.01 |
Pathological grade (low as reference) | ||||||
 High | 2.33 | 1.19–4.56 | 0.01 | 1.82 | 0.89–3.72 | 0.10 |
Lymph node (negative or NA as reference) | ||||||
 Positive | 6.14 | 4.17–9.05 | < 0.01 | 4.28 | 2.83–6.24 | < 0.01 |
TOP2A expression (low as reference) | ||||||
 High | 2.09 | 1.25–3.49 | < 0.01 | 1.42 | 0.81–2.46 | 0.21 |
Ki67 expression (low as reference) | ||||||
 High | 2.98 | 1.53–5.88 | < 0.01 | 2.01 | 0.89–4.60 | 0.10 |