Fig. 7
From: Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations
Analysis of SDH inhibition effects upon retinoic acid-induced differentiation of SH-SY5Y neuroblastoma cells. a Representative confocal microscopy images of SH-SY5Y cells treated with SDH complex inhibitor diethyl malonate (DEM, 5 mM) and/or all-trans retinoic acid (ATRA, 12 μM), visualized with actin and DAPI staining. b Quantification of neurite lengths for individual cells obtained via automated image analysis in CellProfiler (N > 40 cells per condition,* Wilcox rank sum p-value <1E-4)