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Fig. 6 | BMC Cancer

Fig. 6

From: Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo

Fig. 6

Intratumoral injection of miR-335 suppresses tumor growth and regulates CDH11 expression by targeting its promoter 3’UTR site in xenografts. a Graph showing the effect of intratumoral injection of miR-NC, miR-335 mimic or miR-335 inhibitor in complex with in vivo-jetPEI at the arrow-indicated time points on tumor growth. b Graphical representation of the effect of miR-NC, miR-335 mimic or miR-335 inhibitor on CDH11 luciferase activity by targeting the specified target sites, as determined by luciferase reporter assays in MCF7 or MDA-MB-231 cells. *p < 0.05; **p < 0.01; ***p < 0.001

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