Fig. 2
From: Blocking podoplanin suppresses growth and pulmonary metastasis of human malignant melanoma
SZ168 inhibits platelet aggregation induced by human cancer cells with PDPN expression. (a) C8161 cells were pre-incubated with control mouse IgG (20 μg/mL), SZ168 (20, 15 μg/mL), or SZ163 (20 μg/mL). (b) CNE-2 cells were pre-incubated with control mouse IgG (25 μg/mL), SZ168 (25, 20 μg/mL), or SZ163 (25 μg/mL). (c) CHO/hPDPN and (d) NCI-H226 cells were pre-incubated with control mouse IgG (15 μg/mL), SZ168 (15, 10 μg/mL), or SZ163 (15 μg/mL). All cells were then incubated with 250 μL PRP to examine platelet aggregation in a lumi-aggregometer