Fig. 5
From: A new mouse model to study the role of ectopic Nanos3 expression in cancer
Ectopic Nanos3 expression aggravates bronchiolar hyperplasia in NSCLC mice. a. Our mouse model for NSCLC showed bronchiolar hyperplasia compared to Cre-negative control mice. Ectopic Nanos3 overexpression strongly enhanced this bronchiolar phenotype. Representative sections are shown. b. Three Cre-negative mice (Nanos3LSL/−;LSL-KRasG12D;p53fl/fl;CCSP-rtTA+/−;TetO-Cre−/−), five Cre-positive control NSCLC mice (LSL-KRasG12D;p53fl/fl;CCSP-rtTA+/−;TetO-Cre+/−) and five Nanos3 NSCLC mice (Nanos3LSL/−;LSL-KRasG12D;p53fl/fl;CCSP-rtTA+/−;TetO-Cre+/−) were analyzed. The ratio of bronchiolar hyperplasia to the perimeter of the bronchiole was measured in four randomly chosen bronchioles per mouse. The plot shows the average for each mouse. Error bars, SEM; *: P ≤ 0.05 and **: P ≤ 0.01. Bars: 100 μm