TY - JOUR AU - Andries, Vanessa AU - De Keuckelaere, Evi AU - Staes, Katrien AU - Hochepied, Tino AU - Taminau, Joachim AU - Lemeire, Kelly AU - Birembaut, Philippe AU - Berx, Geert AU - van Roy, Frans PY - 2019 DA - 2019/06/17 TI - A new mouse model to study the role of ectopic Nanos3 expression in cancer JO - BMC Cancer SP - 598 VL - 19 IS - 1 AB - NANOS3 is a gene conserved throughout evolution. Despite the quite low conservation of Nanos sequences between different organisms and even between Nanos paralogs, their role in germ cell development is remarkably universal. Human Nanos3 expression is normally restricted to the gonads and the brain. However, ectopic activation of this gene has been detected in various human cancers. Until now, Nanos3 and other Nanos proteins have been studied almost exclusively in germ cell development. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-019-5807-x DO - 10.1186/s12885-019-5807-x ID - Andries2019 ER -