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Table 2 components of Metabolic signatures for liver- and pancreatic cancer cell lines. The spearman corrections were generated between simulated values of components in the model MCPM and IC50 values of RTK inhibitor treatments on corresponding both cancer cell lines. The Benferroni correction was applied

From: Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures

Metabolic Signatures
Liver Cancer Pancreatic Cancer
Components Correlation / p-value Pathways Components Correlation / p-value Pathways
trans-Dodec-2-enoyl-[acp] −0.293 / 2.59E-07 Fatty_acid_metabolism PDHA1 0.125 / 2.22E-07 Pyruvate_metabolism,Glycolysis_/_Gluconeogenesis,TCA_cycle
SUCLG1 −0.202 / 2.33E-07 Propanoate_metabolism, Citrate_cycle_(TCA_cycle) CYB5RL 0.244 / 1.68E-07 Amino_Nucleotide_sugar_metabolism
trans-Tetradec-2-enoyl-[acp] −0.293 / 2.59E-07 Fatty_acid_metabolism HNMT 0.335 / 2.24E-07 Histidine_metabolism
NAGS −0.267 / 2.83E-07 Fatty_acid_metabolism ACOX1 −0.306 / 1.20E-07 Fatty_acid_metabolism,Butanoate_metabolism
(R)-3-Hydroxyhexanoyl-[acp] −0.328 / 2.02E-07 Fatty_acid_metabolism TAT −0.224 / 2.82E-07 Cysteine_and_methionine_metabolism,Tyrosine_metabolism
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] −0.328 / 2.02E-07 Fatty_acid_metabolism ENTPD5 −0.297 / 1.23E-07 Pyrimidine_metabolism,Purine_metabolism
PFKM −0.260 / 2.07E-07 Fructose_and_mannose_metabolism,Glycolysis/Gluconeogenesis,Pentose_phosphate_pathway,Galactose_metabolism NMNAT2 0.256 / 2.06E-07 Nicotinate_and_nicotinamide_metabolism
trans-Hexadec-2-enoyl-[acp] −0.297 / 2.59E-07 Fatty_acid_metabolism PCCA −0.241 / 1.75E-07 Glyoxylate_and_dicarboxylate_metabolism,Valine_leucine_and_isoleucine_degradation
Dodecanoyl-[acyl-carrier protein] −0.328 / 2.02E-07 Fatty_acid_metabolism NAT8L −0.218 / 2.54E-07 Alanine_aspartate_and_glutamate_metabolism
trans-Hex-2-enoyl-[acp] −0.293 / 2.59E-07 Fatty_acid_metabolism NAD+ −0.264 / 1.75E-07 28 metabolic pathways
D-Glucose −0.316 / 1.92E-07 Starch_and_sucrose_metabolism,Galactose_metabolism H+ −0.185 / 1.56E-07 28 metabolic pathways
Tetradecanoyl-[acp] −0.328 / 2.02E-07 Fatty_acid_metabolism Ferrocytochrome b5 0.244 / 1.68E-07 Amino_Nucleotide_sugar_metabolism
NUDT16 −0.324 / 1.99E-07 Purine_metabolism    
(R)-3-Hydroxydodecanoyl-[acp] −0.328 / 2.02E-07 Fatty_acid_metabolism    
Butyryl-[acp] −0.328 / 2.02E-07 Fatty_acid_metabolism    
Decanoyl-[acp] −0.328 / 2.02E-07 Fatty_acid_metabolism    
Octanoyl-[acp] −0.328 / 2.02E-07 Fatty_acid_metabolism    
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] −0.328 / 2.02E-07 Fatty_acid_metabolism    
Hexanoyl-[acp] −0.328 / 2.02E-07 Fatty_acid_metabolism    
2-Deoxyinosine 5-phosphate −0.330 / 1.89E-07 Purine_metabolism    
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