Table 2 components of Metabolic signatures for liver- and pancreatic cancer cell lines. The spearman corrections were generated between simulated values of components in the model MCPM and IC50 values of RTK inhibitor treatments on corresponding both cancer cell lines. The Benferroni correction was applied
Metabolic Signatures | |||||
|---|---|---|---|---|---|
Liver Cancer | Pancreatic Cancer | ||||
Components | Correlation / p-value | Pathways | Components | Correlation / p-value | Pathways |
trans-Dodec-2-enoyl-[acp] | −0.293 / 2.59E-07 | Fatty_acid_metabolism | PDHA1 | 0.125 / 2.22E-07 | Pyruvate_metabolism,Glycolysis_/_Gluconeogenesis,TCA_cycle |
SUCLG1 | −0.202 / 2.33E-07 | Propanoate_metabolism, Citrate_cycle_(TCA_cycle) | CYB5RL | 0.244 / 1.68E-07 | Amino_Nucleotide_sugar_metabolism |
trans-Tetradec-2-enoyl-[acp] | −0.293 / 2.59E-07 | Fatty_acid_metabolism | HNMT | 0.335 / 2.24E-07 | Histidine_metabolism |
NAGS | −0.267 / 2.83E-07 | Fatty_acid_metabolism | ACOX1 | −0.306 / 1.20E-07 | Fatty_acid_metabolism,Butanoate_metabolism |
(R)-3-Hydroxyhexanoyl-[acp] | −0.328 / 2.02E-07 | Fatty_acid_metabolism | TAT | −0.224 / 2.82E-07 | Cysteine_and_methionine_metabolism,Tyrosine_metabolism |
(3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] | −0.328 / 2.02E-07 | Fatty_acid_metabolism | ENTPD5 | −0.297 / 1.23E-07 | Pyrimidine_metabolism,Purine_metabolism |
PFKM | −0.260 / 2.07E-07 | Fructose_and_mannose_metabolism,Glycolysis/Gluconeogenesis,Pentose_phosphate_pathway,Galactose_metabolism | NMNAT2 | 0.256 / 2.06E-07 | Nicotinate_and_nicotinamide_metabolism |
trans-Hexadec-2-enoyl-[acp] | −0.297 / 2.59E-07 | Fatty_acid_metabolism | PCCA | −0.241 / 1.75E-07 | Glyoxylate_and_dicarboxylate_metabolism,Valine_leucine_and_isoleucine_degradation |
Dodecanoyl-[acyl-carrier protein] | −0.328 / 2.02E-07 | Fatty_acid_metabolism | NAT8L | −0.218 / 2.54E-07 | Alanine_aspartate_and_glutamate_metabolism |
trans-Hex-2-enoyl-[acp] | −0.293 / 2.59E-07 | Fatty_acid_metabolism | NAD+ | −0.264 / 1.75E-07 | 28 metabolic pathways |
D-Glucose | −0.316 / 1.92E-07 | Starch_and_sucrose_metabolism,Galactose_metabolism | H+ | −0.185 / 1.56E-07 | 28 metabolic pathways |
Tetradecanoyl-[acp] | −0.328 / 2.02E-07 | Fatty_acid_metabolism | Ferrocytochrome b5 | 0.244 / 1.68E-07 | Amino_Nucleotide_sugar_metabolism |
NUDT16 | −0.324 / 1.99E-07 | Purine_metabolism |  |  |  |
(R)-3-Hydroxydodecanoyl-[acp] | −0.328 / 2.02E-07 | Fatty_acid_metabolism |  |  |  |
Butyryl-[acp] | −0.328 / 2.02E-07 | Fatty_acid_metabolism |  |  |  |
Decanoyl-[acp] | −0.328 / 2.02E-07 | Fatty_acid_metabolism |  |  |  |
Octanoyl-[acp] | −0.328 / 2.02E-07 | Fatty_acid_metabolism |  |  |  |
(3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] | −0.328 / 2.02E-07 | Fatty_acid_metabolism |  |  |  |
Hexanoyl-[acp] | −0.328 / 2.02E-07 | Fatty_acid_metabolism |  |  |  |
2-Deoxyinosine 5-phosphate | −0.330 / 1.89E-07 | Purine_metabolism |  |  |  |