Table 2 List of ECM remodeling proteins identified in PSC secretome
Accession | Protein description | Gene symbol | Molecular weight [kDa] | Coverage |
|---|---|---|---|---|
P02751 | Fibronectin | FN1 | 262.5 | 66.7 |
P08123 | Collagen alpha-2(I) chain | COL1A2 | 129.2 | 82.3 |
P02452 | Collagen alpha-1(I) chain | COL1A1 | 138.9 | 81.1 |
P02461 | Collagen alpha-1(III) chain | COL3A1 | 138.5 | 55.3 |
P12109 | Collagen alpha-1(VI) chain | COL6A1 | 108.5 | 61.1 |
P35555 | Fibrillin-1 | FBN1 | 312.0 | 44.7 |
P12111 | Collagen alpha-3(VI) chain | COL6A3 | 343.5 | 48.1 |
P08253 | 72 kDa type IV collagenase | MMP2 | 73.8 | 73.5 |
Q99715 | Collagen alpha-1(XII) chain | COL12A1 | 332.9 | 35.0 |
P11047 | Laminin subunit gamma-1 | LAMC1 | 177.5 | 38.1 |
P98160 | Heparan sulfate proteoglycan core protein | HSPG2 | 468.5 | 26.3 |
P08572 | Collagen alpha-2(IV) chain | COL4A2 | 167.4 | 41.1 |
P03956 | Interstitial collagenase | MMP1 | 54.0 | 65.9 |
P05997 | Collagen alpha-2(V) chain | COL5A2 | 144.8 | 50.9 |
P01033 | Metalloproteinase inhibitor 1 | TIMP1 | 23.2 | 58.9 |
P20908 | Collagen alpha-1(V) chain | COL5A1 | 183.4 | 21.0 |
P07585 | Decorin | DCN | 39.7 | 54.3 |
P12110 | Collagen alpha-2(VI) chain | COL6A2 | 108.5 | 44.2 |
P16035 | Metalloproteinase inhibitor 2 | TIMP2 | 24.4 | 67.7 |
P07942 | Laminin subunit beta-1 | LAMB1 | 197.9 | 32.7 |
P02462 | Collagen alpha-1(IV) chain | COL4A1 | 160.5 | 15.5 |
P14543 | Nidogen-1 | NID1 | 136.3 | 23.4 |
P12107 | Collagen alpha-1(XI) chain | COL11A1 | 181.0 | 14.2 |
P01023 | Alpha-2-macroglobulin | A2M | 163.2 | 33.2 |
P07858 | Cathepsin B | CTSB | 37.8 | 46.3 |
P13497 | Bone morphogenetic protein 1 | BMP1 | 111.2 | 26.7 |
P16112 | Aggrecan core protein | ACAN | 250.0 | 10.2 |
P16070 | CD44 antigen | CD44 | 81.5 | 6.3 |
Q13443 | Disintegrin and metalloproteinase domain-containing protein 9 | ADAM9 | 90.5 | 5.5 |
P13796 | Plastin-2 | LCP1 | 70.2 | 12.8 |
Q07092 | Collagen alpha-1(XVI) chain | COL16A1 | 157.7 | 5.9 |
P27658 | Collagen alpha-1(VIII) chain | COL8A1 | 73.3 | 18.1 |
P07339 | Cathepsin D | CTSD | 44.5 | 38.3 |
P08254 | Stromelysin-1 | MMP3 | 53.9 | 24.1 |
P35556 | Fibrillin-2 | FBN2 | 314.6 | 4.1 |
Q05707 | Collagen alpha-1(XIV) chain | COL14A1 | 193.4 | 9.4 |
Q13751 | Laminin subunit beta-3 | LAMB3 | 129.5 | 8.7 |
Q13753 | Laminin subunit gamma-2 | LAMC2 | 130.9 | 8.5 |
O14672 | Disintegrin and metalloproteinase domain-containing protein 10 | ADAM10 | 84.1 | 15.1 |
P07711 | Cathepsin L1 | CTSL1 | 37.5 | 20.4 |
P10451 | Osteopontin | SPP1 | 35.4 | 19.1 |
P17813 | Endoglin | ENG | 70.5 | 8.2 |
Q16787 | Laminin subunit alpha-3 | LAMA3 | 366.4 | 2.8 |
P39059 | Collagen alpha-1(XV) chain | COL15A1 | 141.6 | 6.2 |
P39060 | Collagen alpha-1(XVIII) chain | COL18A1 | 178.1 | 5.2 |
P25940 | Collagen alpha-3(V) chain | COL5A3 | 172.0 | 2.7 |
P43235 | Cathepsin K | CTSK | 36.9 | 5.5 |