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Table 2 List of ECM remodeling proteins identified in PSC secretome

From: Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

Accession Protein description Gene symbol Molecular weight [kDa] Coverage
P02751 Fibronectin FN1 262.5 66.7
P08123 Collagen alpha-2(I) chain COL1A2 129.2 82.3
P02452 Collagen alpha-1(I) chain COL1A1 138.9 81.1
P02461 Collagen alpha-1(III) chain COL3A1 138.5 55.3
P12109 Collagen alpha-1(VI) chain COL6A1 108.5 61.1
P35555 Fibrillin-1 FBN1 312.0 44.7
P12111 Collagen alpha-3(VI) chain COL6A3 343.5 48.1
P08253 72 kDa type IV collagenase MMP2 73.8 73.5
Q99715 Collagen alpha-1(XII) chain COL12A1 332.9 35.0
P11047 Laminin subunit gamma-1 LAMC1 177.5 38.1
P98160 Heparan sulfate proteoglycan core protein HSPG2 468.5 26.3
P08572 Collagen alpha-2(IV) chain COL4A2 167.4 41.1
P03956 Interstitial collagenase MMP1 54.0 65.9
P05997 Collagen alpha-2(V) chain COL5A2 144.8 50.9
P01033 Metalloproteinase inhibitor 1 TIMP1 23.2 58.9
P20908 Collagen alpha-1(V) chain COL5A1 183.4 21.0
P07585 Decorin DCN 39.7 54.3
P12110 Collagen alpha-2(VI) chain COL6A2 108.5 44.2
P16035 Metalloproteinase inhibitor 2 TIMP2 24.4 67.7
P07942 Laminin subunit beta-1 LAMB1 197.9 32.7
P02462 Collagen alpha-1(IV) chain COL4A1 160.5 15.5
P14543 Nidogen-1 NID1 136.3 23.4
P12107 Collagen alpha-1(XI) chain COL11A1 181.0 14.2
P01023 Alpha-2-macroglobulin A2M 163.2 33.2
P07858 Cathepsin B CTSB 37.8 46.3
P13497 Bone morphogenetic protein 1 BMP1 111.2 26.7
P16112 Aggrecan core protein ACAN 250.0 10.2
P16070 CD44 antigen CD44 81.5 6.3
Q13443 Disintegrin and metalloproteinase domain-containing protein 9 ADAM9 90.5 5.5
P13796 Plastin-2 LCP1 70.2 12.8
Q07092 Collagen alpha-1(XVI) chain COL16A1 157.7 5.9
P27658 Collagen alpha-1(VIII) chain COL8A1 73.3 18.1
P07339 Cathepsin D CTSD 44.5 38.3
P08254 Stromelysin-1 MMP3 53.9 24.1
P35556 Fibrillin-2 FBN2 314.6 4.1
Q05707 Collagen alpha-1(XIV) chain COL14A1 193.4 9.4
Q13751 Laminin subunit beta-3 LAMB3 129.5 8.7
Q13753 Laminin subunit gamma-2 LAMC2 130.9 8.5
O14672 Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 84.1 15.1
P07711 Cathepsin L1 CTSL1 37.5 20.4
P10451 Osteopontin SPP1 35.4 19.1
P17813 Endoglin ENG 70.5 8.2
Q16787 Laminin subunit alpha-3 LAMA3 366.4 2.8
P39059 Collagen alpha-1(XV) chain COL15A1 141.6 6.2
P39060 Collagen alpha-1(XVIII) chain COL18A1 178.1 5.2
P25940 Collagen alpha-3(V) chain COL5A3 172.0 2.7
P43235 Cathepsin K CTSK 36.9 5.5