Fig. 4

Proteome profiling of PSC-CM. Conditioned medium from ten different PSC cultures were subjected to proteomics analysis using LC-MS/MS. a Top five KEGG pathways identified. b The proteins detected by LC-MS/MS were interrogated in terms of functional annotation by DAVID Bioinformatics Resource tool. The representative GO terms cluster groups with top 10 enrichment score are presented. The horizontal axis represents the significance (p value) for each term, while the vertical axis represents the GO categories for biological processes. c STRING network map of proteins involved in ECM remodeling and their categories based on molecular function. ECM, extracellular matrix; ES, enrichment score; FDR, false discovery rate; GO, gene ontology; KEGG, kyoto encyclopedia of genes and genomes; PSC, pancreatic stellate cell; STRING search tool for the retrieval of interacting genes/proteins