Fig. 8

M1 macrophage infiltration fraction is negatively associated with MLH1 expression but positively associated with PD-L1 expression in colon cancer patients. a Un-supervised clustering heatmaps showed the spearman correlation efficient between MLH1 expression and cibersort fraction of 22 immune associated cell types from 6 colon cancer patients’ datasets. b Un-supervised clustering heatmaps showed the spearman correlation efficient between PD-L1 expression and cibersort fraction of 22 immune associated cell types from 6 colon cancer patients’ datasets. c A graphical picture showed the MSI signature with the inactivation of MMR system, TGFβ signaling pathway and Wnt signaling pathway, but with the activation of PD-L1 expression, IFN-γ signature, IRF1 transcription factor activation and T cell signaling activation. The high infiltrations of M1 macrophage and CD8 T cells may contribute those signatures in MSI subtype colon cancer patients