Table 3 Results of simulations
Design | toxicity | patients | DLTs | study length (1.0/wk) | number skipped (1.0/wk) | study length (1.5/wk) | number skipped (1.5/wk) | MTD |
|---|---|---|---|---|---|---|---|---|
STARPAC | T1 | 12.2 (12.2, 12.7) | 3.28 (3.20, 3.54) | 15.8 (15.8, 16.1) | 3.47 (3.47, 3.76) | 13.2 (13.0, 13.6) | 7.32 (7.32, 7.67) | 0.342 (0.317, 0.363) |
TITE-CRM | T1 | 14.5 (14.5, 15.3) | 4.23 (4.23, 4.66) | 19.1 (19.1, 19.9) | 4.27 (4.27, 4.57) | 16.2 (15.9, 16.3) | 9.07 (9.07, 9.41) | 0.217 (0.162, 0.217) |
3 + 3 | T1 | 10.2 (10.1, 10.4) | 2.64 (2.62, 2.71) | 20.9 (20.9, 22.2) | 9.90 (9.90, 10.28) | 17.9 (17.9, 19.0) | 14.44 (14.41, 14.95) | 0.234 (0.234, 0.260) |
STARPAC | T2 | 12.5 (12.4, 13.2) | 3.01 (2.97, 3.30) | 16.2 (16.2, 16.5) | 3.70 (3.67, 3.75) | 13.2 (13.2, 14.1) | 7.57 (7.50, 8.09) | 0.163 (0.117, 0.174) |
TITE-CRM | T2 | 14.0 (13.8, 14.3) | 3.66 (3.59, 3.81) | 18.3 (17.9, 18.3) | 4.15 (4.04, 4.15) | 15.4 (14.9, 15.4) | 8.90 (8.43, 8.95) | 0.118 (0.070, 0.118) |
3 + 3 | T2 | 11.1 (11.1, 11.1) | 2.59 (2.59, 2.63) | 23.2 (23.2, 24.2) | 10.95 (10.95, 11.17) | 19.7 (19.7, 20.7) | 16.05 (16.05, 16.31) | 0.127 (0.127, 0.144) |
STARPAC | T3 | 13.2 (13.0, 13.7) | 2.74 (2.68, 2.90) | 17.1 (17.1, 17.4) | 3.86 (3.82, 4.11) | 13.9 (13.9, 14.8) | 7.87 (7.87, 8.38) | 0.468 (0.441, 0.506) |
TITE-CRM | T3 | 13.0 (12.7, 13.2) | 2.88 (2.85, 3.02) | 17.0 (16.3, 17.0) | 3.87 (3.71, 3.87) | 14.0 (13.7, 14.1) | 8.00 (7.90, 8.12) | 0.637 (0.637, 0.708) |
3 + 3 | T3 | 11.9 (11.9, 12.2) | 2.39 (2.39, 2.43) | 25.3 (25.3, 27.1) | 12.18 (12.18, 12.67) | 21.6 (21.6, 23.2) | 17.93 (17.93, 18.75) | 0.165 (0.141, 0.168) |
STARPAC | T4 | 15.0 (14.7, 15.6) | 2.23 (2.16, 2.37) | 19.5 (19.4, 19.7) | 4.60 (4.58, 4.64) | 15.8 (15.8, 16.8) | 8.90 (8.90, 9.69) | 0.728 (0.691, 0.776) |
TITE-CRM | T4 | 11.4 (10.9, 11.6) | 1.71 (1.63, 1.82) | 14.6 (14.6, 15.0) | 3.32 (3.19, 3.40) | 12.3 (11.8, 12.5) | 7.04 (6.59, 7.04) | 0.895 (0.879, 0.932) |
3 + 3 | T4 | 13.2 (13.2, 13.4) | 1.79 (1.78, 1.82) | 29.2 (29.2, 29.9) | 14.12 (14.12, 14.84) | 24.9 (24.9, 25.7) | 20.81 (20.81, 21.85) | 0.456 (0.443, 0.473) |
STARPAC | T5 | 12.8 (12.7, 13.3) | 3.59 (3.54, 3.81) | 16.5 (16.4, 17.0) | 3.74 (3.74, 3.88) | 13.7 (13.6, 14.2) | 7.41 (7.41, 8.08) | 0.444 (0.439, 0.476) |
TITE-CRM | T5 | 16.6 (16.5, 17.0) | 5.11 (5.11, 5.51) | 21.6 (21.5, 22.3) | 5.08 (4.92, 5.17) | 18.2 (17.9, 18.6) | 10.66 (10.44, 10.72) | 0.347 (0.255, 0.347) |
3 + 3 | T5 | 9.9 (9.9, 10.1) | 2.65 (2.65, 2.68) | 20.4 (20.4, 21.7) | 9.55 (9.55, 9.98) | 17.3 (17.3, 18.7) | 13.91 (13.91, 14.68) | 0.349 (0.332, 0.349) |