Fig. 2

miR-890 binds to CD147 3’UTR. a Predicted binding site of miR-890 in 3′-UTR of CD147 gene; b Effects of miR-890 on the expression of a luciferase cassette with the CD147 3′-UTR. 293TN cells were transfected with pGL3-wt-CD147 or pGL3-mt- CD147 in the presence or absence of miR-890-mimic or inhibitor and subjected to luciferase activity assay 48 h later. The histogram shows the relative firefly luciferase activity for the different experimental groups. *, P < 0.05, and **, P < 0.01. Data are expressed as mean ± SD of at least three independent experiments