Thyroid transcription factor-1 as a prognostic indicator for stage IV lung adenocarcinoma with and without EGFR-sensitizing mutations

Table 3 Cox proportional hazards model of overall survival for the 173 patients with lung adenocarcinoma

Predictor variable vs. reference variable	Univariate analysis		Multivariate analysis
Predictor variable vs. reference variable	P value	HR (95% CI)	P value	Adjusted HR (95% CI)
Age (< 70) vs. ≥ 70	0.147	0.783 (0.562–1.090)	0.557	0.897 (0.625–1.288)
Female vs. male	0.001	0.562 (0.398–0.793)	0.410	0.763 (0.400–1.454)
Never smoker vs. ever smoker	0.001	0.563 (0.400–0.792)	0.794	0.917 (0.478–1.759)
Stage IV, M1a vs. M1b	0.103	0.738 (0.513–1.063)	0.005	0.586 (0.405–0.849)
ECOG 0 vs. 1–2	< 0.001	0.461 (0.325–0.654)	0.001	0.522 (0.356–0.764)
EGFR sensitizing mutation vs. wild type	< 0.001	0.497 (0.355–0.696)	0.022	0.640 (0.438–0.937)
TTF-1 positive vs. negative	< 0.001	0.319 (0.212–0.480)	< 0.001	0.395 (0.254–0.615)

Abbreviations: HR Hazard ratio, CI confidence intervals, ECOG Eastern Cooperative Oncology Group, EGFR epidermal growth factor receptor, TTF-1 thyroid transcription factor 1

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