Breast cancer
|
Elisa Pierpaoli, 2015, Italy [10]
|
mice, FVB/N, F, 4w
|
SK-BR-3
|
2.5 mg/kg
|
biw
|
ip
|
32.5w
|
DMSO
|
VD
|
16.81
|
7.24
|
10
|
12.09
|
1.98
|
10
|
0.07
|
Yuwan Zhao, 2017, China [11]
|
mice, BALB/c, F, 6w
|
MDA-MB-231
|
100 mg/kg
|
tiw
|
po
|
3w
|
DMSO
|
TV
|
2.70
|
0.18
|
7
|
0.68
|
0.08
|
7
|
< 0.01
|
BW
|
24.40
|
0.69
|
7
|
22.48
|
0.81
|
7
|
< 0.01
|
Alaa Refaat, 2013, Japan [12]
|
mice, BALB/c, F, 6w
|
4 T1
|
100 mg/kg
|
qd
|
po
|
4.3w
|
CMC
|
TW
|
0.21
|
0.01
|
6
|
0.15
|
0.01
|
6
|
< 0.01
|
Sangmin Kim, 2018, Korea [13]
|
mice, Balb/c, F, 6-8w
|
MDA-MB-231
|
0.1% BBR in the drinking water
|
Daily free intake
|
po
|
6.6w
|
–
|
TV
|
0.42
|
0.18
|
5
|
0.21
|
0.08
|
5
|
0.05
|
Kalyani Chowdary Karnam, 2017, India [14]
|
rats, SD, F, 6.4–8.3w
|
Induced by DMBA
|
50 mg/kg [pretreatment]
|
tiw
|
po
|
4w
|
Corn oil
|
TV
|
3.79
|
0.90
|
6
|
0.63
|
0.30
|
6
|
< 0.01
|
TW
|
9.64
|
0.90
|
6
|
3.80
|
0.99
|
6
|
< 0.01
|
50 mg/kg [posttreatment]
|
TV
|
3.79
|
0.90
|
6
|
1.31
|
0.60
|
6
|
< 0.01
|
TW
|
9.64
|
0.90
|
6
|
5.71
|
1.32
|
6
|
< 0.01
|
Elisa Damiani, 2015, Italy [15]
|
miceFVB/NF4w
|
HER2/neu transgenic mice
|
2.5 mg/kg
|
biw
|
ip
|
NR
|
Sterile saline
|
VD
|
16.77
|
5.31
|
7
|
11.07
|
1.75
|
9
|
0.03
|
Ke Su, 2016, China [16]
|
mice, Balb/c, F, 6w
|
MDA-MB-231
|
10 mg/kg
|
q4d
|
ip
|
3w
|
DMSO
|
TV
|
0.59
|
0.27
|
6
|
0.27
|
0.12
|
6
|
0.02
|
TW
|
0.50
|
0.11
|
6
|
0.29
|
0.06
|
6
|
< 0.01
|
BW
|
22.59
|
7.31
|
6
|
19.10
|
3.71
|
6
|
0.32
|
Liver cancer
|
Guan-Yu Wang, 2009, China [17]
|
mice, Balb/c, M, 6w
|
HEPG2
|
40 mg/kg
|
qd
|
ip
|
1.4w
|
Saline
|
TV
|
3.31
|
0.38
|
5
|
2.21
|
0.22
|
6
|
< 0.01
|
BW
|
3.13
|
0.43
|
5
|
4.62
|
0.41
|
6
|
< 0.01
|
80 mg/kg
|
TV
|
3.31
|
0.38
|
5
|
1.43
|
0.13
|
5
|
< 0.01
|
BW
|
3.13
|
0.43
|
5
|
3.74
|
0.36
|
5
|
0.04
|
Jing Li, 2015, Canada [18]
|
mice, Balb/c, NR, 6-8w
|
H22
|
50 mg/kg
|
qd
|
po
|
2w
|
Water
|
TV
|
4.24
|
0.56
|
10
|
0.33
|
0.35
|
10
|
< 0.01
|
Chi Man Tsang, 2015, China [19]
|
mice, NR, NR, NR
|
MHCC-97 L-luciferase
|
10 mg/kg
|
qod
|
ip
|
5w
|
Saline
|
TV
|
1.00
|
0.05
|
7
|
0.21
|
0.03
|
7
|
< 0.01
|
VD
|
12.58
|
2.94
|
7
|
2.18
|
1.29
|
7
|
< 0.01
|
Colon cancer
|
Norio Iizuka, 2002, Japan [20]
|
mice, Balb/c, M, 6w
|
Colon26/clone 20
|
0.1% BBR in the driNRing water
|
Daily free intake
|
po
|
2w
|
–
|
TW
|
0.22
|
0.15
|
9
|
0.25
|
0.12
|
9
|
0.65
|
BW
|
18.20
|
1.50
|
9
|
18.40
|
1.80
|
9
|
0.80
|
0.2% BBR in the driNRing water
|
TW
|
0.22
|
0.15
|
9
|
0.25
|
0.15
|
9
|
0.68
|
BW
|
18.20
|
1.50
|
9
|
22.20
|
1.50
|
9
|
< 0.01
|
0.4% BBR in the driNRing water
|
TW
|
0.22
|
0.15
|
9
|
0.24
|
0.18
|
9
|
0.80
|
BW
|
18.20
|
1.50
|
9
|
20.90
|
4.20
|
9
|
0.10
|
H Ruan, 2017, China [21]
|
mice, Balb/c, NR, 6-7w
|
KM12C/shCtrl
|
10 mg/kg
|
qd
|
ip
|
2w
|
DMSO
|
TV
|
1.26
|
0.97
|
6
|
0.79
|
0.53
|
6
|
0.32
|
KM12C/shRXRα
|
1.54
|
0.92
|
6
|
1.40
|
0.46
|
6
|
0.76
|
Yuchen Cai, 2013, Japan [22]
|
mice, Balb/c, NR, 5w
|
HT-29
|
10 mg/kg
|
qd
|
po
|
2w
|
Sterile water
|
TV
|
6.11
|
3.01
|
10
|
4.33
|
2.42
|
10
|
0.16
|
BW
|
6.60
|
3.60
|
10
|
4.90
|
3.20
|
10
|
0.28
|
30 mg/kg
|
TV
|
6.11
|
3.01
|
10
|
4.09
|
1.76
|
10
|
0.08
|
BW
|
6.60
|
3.60
|
10
|
3.90
|
2.70
|
10
|
0.07
|
50 mg/kg
|
TV
|
6.11
|
3.01
|
10
|
3.34
|
1.31
|
11
|
0.01
|
BW
|
6.60
|
3.60
|
10
|
3.60
|
2.50
|
11
|
0.04
|
nasopharyngeal carcinoma
|
Chao Wang, 2017, China [23]
|
mice, NOD/SCID, F, 8w
|
HONE-1
|
10 mg/kg
|
tiw
|
ip
|
3w
|
DMSO
|
TV
|
0.58
|
0.06
|
5
|
0.10
|
0.03
|
5
|
< 0.01
|
TW
|
0.15
|
0.01
|
5
|
0.02
|
0.01
|
5
|
< 0.01
|
Chi Man Tsang, 2013, China [24]
|
mice, NR, M, 6-8w
|
C666–1
|
5 mg/kg
|
qod
|
ip
|
6w
|
DMSO
|
TV
|
0.15
|
0.05
|
5
|
0.04
|
0.03
|
5
|
< 0.01
|
10 mg/kg
|
0.15
|
0.05
|
5
|
0.02
|
0.02
|
4
|
< 0.01
|
Lung cancer
|
Michael A. James, 2011, Missouri [25]
|
mice, Balb/c, M, 4-6w
|
A549
|
1800 ppm
|
Daily free intake
|
po
|
4w
|
DMSO
|
TV
|
0.06
|
0.02
|
3
|
0.02
|
0.02
|
4
|
0.05
|
5400 ppm
|
0.06
|
0.02
|
3
|
0.01
|
0.01
|
2
|
0.04
|
Santosh K. Katiyar, 2009, Alabama [26]
|
mice, Balb/c, F, 6-7w
|
A549
|
50 mg/kg
|
qd
|
po
|
7w
|
PBS
|
TV
|
1.40
|
0.07
|
10
|
0.99
|
0.04
|
10
|
< 0.01
|
TW
|
2.32
|
0.27
|
10
|
2.02
|
0.30
|
10
|
0.03
|
100 mg/kg
|
TV
|
1.40
|
0.07
|
10
|
0.60
|
0.03
|
10
|
< 0.01
|
TW
|
2.32
|
0.27
|
10
|
1.16
|
0.21
|
10
|
< 0.01
|
200 mg/kg
|
TV
|
1.40
|
0.07
|
10
|
0.30
|
0.06
|
10
|
< 0.01
|
TW
|
2.32
|
0.27
|
10
|
0.62
|
0.09
|
10
|
< 0.01
|
H1299
|
50 mg/kg
|
TV
|
1.59
|
0.10
|
10
|
1.36
|
0.05
|
10
|
< 0.01
|
TW
|
2.71
|
0.31
|
10
|
2.36
|
0.29
|
10
|
0.02
|
100 mg/kg
|
TV
|
1.59
|
0.10
|
10
|
1.05
|
0.05
|
10
|
< 0.01
|
TW
|
2.71
|
0.31
|
10
|
1.82
|
0.29
|
10
|
< 0.01
|
200 mg/kg
|
TV
|
1.59
|
0.10
|
10
|
0.61
|
0.02
|
10
|
< 0.01
|
TW
|
2.71
|
0.31
|
10
|
1.15
|
0.10
|
10
|
< 0.01
|
Gastric cancer
|
Junxiong Wang, 2016, China [27]
|
mice, Balb/c, F, 5w
|
BGC823
|
50 mg/kg
|
qd
|
po
|
4w
|
NR
|
TV
|
2.28
|
0.24
|
3
|
0.73
|
0.13
|
3
|
< 0.01
|
TW
|
1.37
|
0.37
|
3
|
0.32
|
0.08
|
3
|
< 0.01
|
BW
|
2.51
|
0.69
|
3
|
0.10
|
0.46
|
3
|
< 0.01
|
Hongli Li, 2016, China [28]
|
mice, Balb/c, M, 4w
|
MGC803
|
15 mg/kg
|
qd
|
po
|
3.3w
|
NR
|
TV
|
0.85
|
0.29
|
6
|
0.44
|
0.09
|
6
|
0.02
|
TW
|
0.68
|
0.18
|
6
|
0.42
|
0.07
|
6
|
< 0.01
|
Neuroepithelial tumor
|
Juan Wang, 2015, China [29]
|
miceBalb/cNN
|
–
|
100 mg/kg
|
qd
|
po
|
3w
|
NR
|
TV
|
0.04
|
0.02
|
8
|
0.02
|
0.00
|
8
|
0.05
|
Yuxue Sun, 2018, China [30]
|
miceBalb/cN6-8w
|
C6
|
10 mg/kg
|
qd
|
ip
|
1w
|
DMSO
|
TV
|
0.77
|
0.22
|
7
|
0.35
|
0.06
|
7
|
< 0.01
|
Endometrial carcinoma
|
Yu Wang, 2018, China [31]
|
mice, Balb/c, NR, 6w
|
HEC-1-A
|
50 mg/kg
|
qd
|
po
|
4w
|
DMSO
|
TV
|
1.01
|
0.13
|
6
|
0.65
|
0.06
|
6
|
< 0.01
|
100 mg/kg
|
1.01
|
0.13
|
6
|
0.34
|
0.04
|
6
|
< 0.01
|
Esophageal cancer
|
Kewei Ren, 2016, China [32]
|
mice, Balb/c, M, 6-8w
|
Eca9706
|
20 mg/kg
|
qd
|
po
|
7w
|
DMSO
|
TV
|
6.37
|
0.25
|
5
|
5.05
|
0.60
|
5
|
< 0.01
|
TW
|
2.66
|
0.29
|
5
|
1.82
|
0.21
|
5
|
< 0.01
|
Tongue squamous cell carcinima
|
Yung-Tsuan Ho, 2009, China [33]
|
mice, Balb/c, F, 6w
|
SCC-4
|
10 mg/kg
|
q4d
|
ip
|
4w
|
DMSO
|
TV
|
0.18
|
0.06
|
6
|
0.03
|
0.02
|
6
|
< 0.01
|
TW
|
0.26
|
0.16
|
6
|
0.12
|
0.09
|
6
|
0.11
|
Cholangiocarcinoma
|
Nattapong Puthdee, 2013, Japan [34]
|
hamster, Syrian, M, 4-5w
|
Ham-1
|
10 mg/kg
|
qd
|
po
|
3w
|
sterile water
|
TW
|
0.70
|
0.18
|
5
|
0.67
|
0.11
|
5
|
0.79
|
Sarcoma
|
Lei Zhang, 2012, China [35]
|
mice, Kunming, NR, 6w
|
S180
|
30 mg/kg
|
qd
|
ip
|
NR
|
NR
|
TW
|
2.20
|
0.93
|
10
|
1.26
|
0.54
|
9
|
0.02
|
BW
|
2.71
|
2.20
|
10
|
−2.54
|
3.24
|
9
|
< 0.01
|