Table 3 Sub analysis of all predictor values of 2-, 5-year, and median overall survival (OS). Data are stratified for postoperative chemo-radiation dose (< 45 Gy, > 45 and 50 Gy, ≥ 50 and < 55 Gy, ≥ 55 Gy)
From: Adjuvant chemoradiation in pancreatic cancer: impact of radiotherapy dose on survival
Variable | Value | OS | Median OS (months) | p value | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2-y (%) | 5-y (%) | |||||||||||||
RT dose (Gy) | < 45 | ≥ 45 and < 50 | ≥ 50 and < 55 | ≥ 55 | < 45 | ≥ 45 and < 50 | ≥ 50 and < 55 | ≥ 55 | < 45 | ≥ 45 and < 50 | ≥ 50 and < 55 | ≥ 55 | ||
OS | 24.0 | 44.6 | 44.9 | 59.5 | 4.0 | 25.1 | 22.0 | 18.4 | 13 | 21 | 22 | 28 | ||
Gender | Male | 45.5 | 43.8 | 49.3 | 58.5 | 9.1 | 33.4 | 22.7 | 27.4 | 20 | 22 | 24 | 28 | .450 |
Female | 7.1 | 45.5 | 41.1 | 60.5 | 0.0 | 20.0 | 21.3 | 10.5 | 11 | 21 | 21 | 29 | <.001 | |
Ca 19.9 (units/mL) | < 90 | 0.0 | 61.5 | 60.3 | 81.0 | 0.0 | 39.1 | 38.3 | 10.3 | 8 | 3 | 35 | 31 | <.001 |
≥ 90 | 0.0 | 9.2 | 37.2 | 61.8 | 0.0 | 0.0 | 15.8 | 32.7 | 12 | 18 | 19 | 27 | .001 | |
Tumor Site | Head | 23.8 | 40.7 | 46.3 | 61.1 | 0.0 | 22.0 | 23.1 | 20.5 | 13 | 20 | 23 | 28 | .001 |
Body | 0.0 | 0.0 | 38.2 | 66.7 | 0.0 | 0.0 | 20.4 | 0.0 | 11 | 17 | 23 | 38 | .258 | |
Tail | 50.0 | 100.0 | 40.3 | 40.0 | 0.0 | – | 11.9 | 0.0 | – | – | – | – | .406 | |
Type of resection | DCP | 30.8 | 42.2 | 45.2 | 61.4 | 0.0 | 28.5 | 25.8 | 19.3 | 11 | 20 | 23 | 28 | .016 |
DP | 33.3 | 75.0 | 40.5 | 54.5 | 33.3 | 75.0 | 14.6 | 0.0 | 20 | NR | 22 | 38 | .339 | |
TP | 0.0 | 25.0 | 19.4 | – | 0.0 | 25.0 | 0.0 | – | NR | NR | NR | NR | <.001 | |
PPP | 20.0 | 47.7 | 49.9 | – | 0.0 | 15.9 | 20.6 | – | 16 | 22 | 24 | 19 | .666 | |
Grading | 1 | – | 20.0 | 66.7 | 75.0 | – | 20.0 | 41.7 | 45.5 | 7 | 21 | 33 | 38 | <.001 |
2 | 80.0 | 57.7 | 45.0 | 58.1 | 20.0 | 42.7 | 18.4 | 0.0 | 30 | 44 | 23 | 28 | .313 | |
3 | 15.4 | 40.0 | 44.5 | 57.1 | – | 20.1 | 21.2 | 18.7 | 13 | 19 | 21 | 27 | .039 | |
4 | – | 50.0 | 33.6 | 33.3 | – | – | 24.0 | – | 11 | 10 | 15 | 19 | .622 | |
Margins status | R0 | 28.6 | 51.9 | 52.9 | 77.5 | 14.3 | 51.9 | 21.4 | 25.3 | 11 | NR | 25 | 32 | .004 |
R1 | – | – | 24.7 | 50.0 | – | – | 12.3 | 10.7 | 10 | 9 | 20 | 24 | <.001 | |
Tumor diameter | < 30 mm | 20.0 | 25.9 | 50.0 | 73.0 | – | 25.9 | 0.0 | 21.3 | 7 | 22 | 23 | 31 | <.001 |
≥ 30 mm | 50.0 | 37.5 | 37.5 | 58.1 | 50.0 | – | 19.4 | 17.9 | 11 | 21 | 21 | 28 | .493 | |
pT-stage | 1 | 100.0 | 75.0 | 66.9 | 100.0 | – | 75.0 | 40.1 | 0.0 | 30 | NR | 35 | 60 | .320 |
2 | 50.0 | 66.7 | 53.2 | 42.9 | 25.0 | 35.0 | 25.5 | 21.4 | 11 | 49 | 25 | 19 | .639 | |
3 | 15.0 | 38.7 | 39.6 | 62.1 | 0.0 | 18.5 | 18.5 | 20.9 | 12 | 17 | 21 | 29 | <.001 | |
4 | – | 0.0 | 31.6 | 50.0 | – | – | 15.8 | 15.0 | NR | 20 | 14 | 24 | .263 | |
pN-stage | N0 | 25.0 | 64.9 | 53.4 | 83.3 | 0.0 | 35.7 | 29.8 | 42.3 | 10 | 36 | 27 | 49 | <.001 |
N+ | 23.5 | 32.4 | 37.7 | 53.0 | 5.9 | 18.9 | 15.6 | 11.4 | 16 | 18 | 20 | 25 | .063 | |
Adjuvant CT | No | 31.6 | 47.7 | 44.0 | 28.6 | 5.3 | 24.0 | 22.5 | 14.3 | 16 | 21 | 21 | 14 | .105 |
Yes | – | 24.4 | 47.5 | 66.7 | – | 24.4 | 17.6 | 20.0 | 10 | 17 | 23 | 30 | <.001 | |