Fig. 4

Reverse Phase protein and phosphoprotein analysis by the TCPA reveals differences in levels of Tp63, p62/SQSTM1, Keap1 and other proteins in TrkB-T1 high expresser LASCs and other SCCS. a Heat map reveals relative log2 protein levels that were differentially abundant based on univariate test at FDR < 0.10 for LASC. Levels in other tumor types are shown. Geometric means are shown. b Box plots show differential expression of Tp63 in high TrkB-T1 expresser LASCs vs. low expressers p < 0.00339, then for OSCC, p < 0.0509, LUSC, p < 0.0001 and adenocarcinoma, LUAD, p < 0.150 determined by Wilcoxon test. Shown are arithmetic means of values. c Similar to B except p62/SQTM1 was measured with differences shown for LASC at p < 0.0184, OSCC p < 0.0299, LUSC p < 0.0001 and LUAD p < 0.986. d Similar to B except Keap1 protein was measured with differences shown for LASC at p < 0.00339, OSCC p < 0.0410, LUSC p < 0.0001 and LUAD p < 0.350