Table 1 Simple linear regression estimates producing estimates of incremental values (i.e., Δ’s)
Regression Subgroup | Simple Linear Regression Estimates of Incremental Net Benefit (p-values) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Effect (in QALYs) | Cost (in $) | NB($0) (amount by which benefits outweigh costs, when an extra QALY is worth $0) | NB($50 k) (amount by which benefits outweigh costs, when an extra QALY is worth $50,000) | NB($100 k) (amount by which benefits outweigh costs, when an extra QALY is worth $100,000) | NB($200 k) (amount by which benefits outweigh costs, when an extra QALY is worth $200,000) | NB($300 k) (amount by which benefits outweigh costs, when an extra QALY is worth $300,000) | NB($400 k) (amount by which benefits outweigh costs, when an extra QALY is worth $400,000) | NB($500 k) (amount by which benefits outweigh costs, when an extra QALY is worth $500,000) | |
KRAS-MUT (n = 150) | −0.0172 (0.4158) | 13,787 (< 0.001) | − 13,787 (< 0.0001) | − 14,650 (< 0.0001) | −15,514 (0.0007) | −17,240 (0.0573) | −18,966 (0.1664) | −20,692 (0.2601) | −22,418 (0.3308) |
KRAS-WT (n = 216) | 0.1769 (< 0.001) | 30,843 (< 0.001) | −30,843 (< 0.0001) | −21,999 (< 0.0001) | − 13,154 (0.0013) | 4536 (0.5734) | 22,226 (0.0715) | 39,916 (0.0167) | 57,606 (0.0062) |
ALL (n = 527) | 0.0771 (0.0011) | 22,210 (< 0.001) | −22,210 (< 0.0001) | −18,358 (< 0.0001) | −14,507 (< 0.0001) | −6805 (0.1789) | 898 (0.9080) | 8600 (0.4129) | 16,303 (0.2186) |