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Table 1 MMPs in Cancer

From: A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential

MMP Role in Cancer
Collagenases
1 Initial invasion, promotes metastasis [5, 6]
8  
13 Growth, invasion, and angiogenesis of skin squamous cell carcinoma [7]
Matrilysins
7 Contributes to invasive potential, proliferation, anti-apoptotic, immune surveillance [1, 8]
26 Activates MMP-9 in prostate cancer, role in early skin carcinogenesis [9, 10]
Metalloelastase
12 Protective inhibition of tumor growth, anti-angiogenic [11]
Stromelysins
3 Invasion, metastasis, and epithelial to mesenchymal transition [12,13,14]
10 Invasion, migration, and growth; prevents tumor cell apoptosis; produces angiogenic and metastatic factors [15,16,17]
11 Produced by peritumoral stromal fibroblasts; regulates early tumor invasion, implantation, and expansion; prevents apoptosis of early cancer cells [18,19,20]
Gelatinases
2 Proteolytic degradation of extracellular proteins in tumor invasion, collagenolytic pathway driver for lymphatic vessel formation, tumor angiogenesis [1, 15, 16]
9 Proteolytic degradation of extracellular proteins during tumor invasion [1, 15]
Enamelysin
20 Synthesized in odontogenic tumors [21]
Membrane-Type
14 Cleaves other pro MMPs (mainly MMP2) to activate them, role in invasive blood vessel growth, and promoting metastasis. In vitro has been shown to promote invasion [22, 23]
15 In vitro shown to play role in epithelial to mesenchymal transition, promotes angiogenesis [24, 25]
16 In vitro promotes invasion and metastasis [26, 27]
17 Induce angiogenesis promote growth and metastasis [25, 28]
24 Progression in brain tumors, aides in migration and metastasis [29, 30]
25 In vitro tumor growth promoter [31]
Other
19 In vitro modulates proliferation, adhesion, and metastasis [32, 33]
21 Expression changes associated with cancer prognosis. [34]
23A Expression levels altered in multiple cancers. Urinary levels decreased in renal cell carcinoma. [35, 36]
23B  
27  
28 Promotes epithelial to mesenchymal transition, promotes invasion and metastasis [37]
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