Intracranial aneurysms formation after radiotherapy for head and neck cancer: a 10-year nationwide follow-up study

Table 1 Baseline characteristics of the NPC-RT, Non-NPC-RT, and Non-NPC-NRT groups

Variables	NPC-RT (n = 15,257)		Non-NPC–RT (n = 39,071)		Non-NPC-NRT (n = 16,363)		P value
Variables	n	%	n	%	n	%
Gender							< 0.0001
Male	11,443	75.00	35,958	92.03	14,500	88.61
Female	3814	25.00	3113	7.97	1863	11.39
Age, years							< 0.0001
< 45	5302	34.75	8250	21.12	3530	21.57
45–65	7949	52.10	23,536	60.24	9265	56.62
> 65	2006	13.15	7285	18.65	3568	21.81
Comorbidities
Arrhythmia							< 0.0001
Yes	1617	10.6	4361	11.16	2144	13.10
No	13,640	89.40	34,710	88.84	14,219	86.90
HTN							< 0.0001
Yes	5845	38.31	16,169	41.38	8166	49.91
No	9412	61.69	22,902	58.62	8197	50.09
DM							< 0.0001
Yes	2694	17.66	9093	23.27	4773	29.17
No	12,563	82.34	29,978	76.73	11,590	70.83
COPD							< 0.0001
Yes	2489	16.31	7198	18.42	3134	19.15
No	12,768	83.69	31,873	81.58	13,229	80.85
Dyslipidemia							< 0.0001
Yes	3837	25.15	9137	23.39	5398	32.99
No	11,420	74.85	29,934	76.61	10,965	67.01
Chronic Kidney disease							< 0.0001
Yes	647	4.24	1728	4.42	879	5.37
No	14,610	95.76	37,343	95.58	15,484	94.63
Coronary artery disease							< 0.0001
Yes	2435	15.96	6599	16.89	3742	22.87
No	12,822	84.04	32,472	83.11	12,621	77.13
Heart failure							< 0.0001
Yes	695	4.56	2219	5.68	1150	7.03
No	14,562	95.44	36,852	94.32	15,213	92.97
Liver cirrhosis							< 0.0001
Yes	443	2.90	3588	9.18	1053	6.44
No	14,814	97.10	35,483	90.82	15,310	93.56
Chemotherapy							< 0.0001
Yes	12,596	82.56	27,637	70.74	1469	8.98
No	2661	17.44	11,434	29.26	14,894	91.02
Intracranial aneurysms
Yes	40	0.26	36	0.09	9	0.06	< 0.0001
No	15,217	99.74	39,035	99.91	16,354	99.94
Death	5014	32.86	21,796	55.79	3548	21.68	< 0.0001

Abbreviations: NPC-RT nasopharyngeal cancer patients with radiotherapy, Non-NPC–RT other head and neck cancer patients with radiotherapy, Non-NPC-NRT other head and neck cancer patients without radiotherapy, HTN hypertension, DM diabetes mellitus, COPD chronic obstructive pulmonary disease

ISSN: 1471-2407