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Table 3 Absolute and relative frequencies of the MPL and CALR mutations

From: Systematization of analytical studies of polycythemia vera, essential thrombocythemia and primary myelofibrosis, and a meta-analysis of the frequency of JAK2, CALR and MPL mutations: 2000–2018

  MPL Mutation CALR Mutation
Author Technique PV % (n) ET % (n) PMF % (n) Technique PV % (n) ET % (n) PMF % (n)
Xu [35] AS-PCR 0 (0) 1.0 (1) 0 (0) ND ND ND ND
Chen [40] AS-PCR 0 (0) 1,4 (1) 5,6 (1) ND ND ND ND
Toyama [41] Sequencing 0 (0) 2,4 (2) 0 (0) ND ND ND ND
Wu [49] Real-time PCR 0 (0) 5,0 (4) 6,0 (3) Sequencing 0(0) 25,0 (2)0) 20,0 (16)
Labastida [55] ARMS 0 (0) 12,5 (1) 0 (0) Fragment analysis 0 (0) 50,0 (4) 25,0 (1)
Trifa [15] SNP 0 (0) 1,4 (2) 4,2 (2) SNP 0 (0) 29,3 (41) 25,0 (12)
Gadomska [70] ND ND 5,3 (1) 0 (0) ND ND 31,6 (6) 100 (2)
Li [72] Sequencing ND 0,9 (9) 1,1 (1) Sequencing ND 12,6 (132) 12,1 (11)
Schnittger S [46] PCR ND 7,1 (44) 13,2 (17) ND ND ND ND
Misawa [73] AS-PCR 0 (0) 4,7 (10) 1,1 (1) Fragment analysis 0 (0) 26,9 (57) 21,6 (19)
Gángó [74] Sequencing ND 1,6 (7) 7,1 (16) Fragment analysis ND 24,5 (104) 21,6 (49)
Lin [58] Sequencing 0 (0) 1,2 (5) 2,7 (5) Sequencing 0 (0) 22,7 (97) 17,6 (33)
Delic [66] Sequencing 0 (0) 5,0 (2) 10 (3) Sequencing 0 (0) 25,0 (10) 10,0 (3)
Orvain [67] Real-time PCR ND 2,2 (2) 17,1 (6) Fragment analysis ND 12,9 (12) 20.0 (7)
Kander [19] ND ND ND ND Fragment analysis ND 33,3 (10) 37,5 (3)
Gardner [65] ND ND ND ND Fragment analysis 0 (0) 33,3 (1) 66,7 (2)
Smaili [69] ND ND ND ND Sequencing ND 50,0 (11) 36,4 (4)
  1. AS-PCR Allele-specific polymerase chain reaction, PCR polymerase chain reaction, ARMS Amplification-refractory mutation system, SNP single-nucleotide polymorphism, ND No Data