Primary endpoint | |
 The disability-free survival | |
Secondary endpoint | |
 1) Lean body mass assessed by CT | |
 2) Physical function assessed by the hand-grip strength, SPPB score and physical activity measured by accelerometer | |
 3) Nutritional status assessed by body weight, MNA score and ingested nutritional quantity | |
 4) Quality of Life assessed by EORTC-QLQ-C30 | |
 5) The proportion of patients treated with subsequent chemotherapy | |
 6) Overall survival, Progression free survival | |
 7) The cumulative number of days of hospitalization | |
 8) Activity of daily life | |
 9) Safety |