Table 1 Demographics

Gender

Female/Male

3/9 (25/75)

Age at inclusion (years)

Median

55

[32–68]

BMI (kg/m²)

Median

29

[25–35]

Etiology^a

Hepatitis C

8 (67)

Hepatitis B

2 (17)

Alcohol

5 (42)

Comorbidity^a

Hypertension

4 (33)

Diabetes

2 (17)

Pulmonary disease

1 (8)

No comorbidity

6 (50)

ECOG at inclusion

0

7 (58)

1

5 (42)

Child–Pugh score at inclusion

5

5 (42)

6

6 (50)

7

1 (8)

MELD^b score at inclusion

9

[6–13]

AFP level at inclusion (mg/L)

Baseline median

22.5

[2.3–2790]

<  100

9 (75)

≥  100

3 (25)

Criteria at inclusion

Within Milan

11 (92)

Within USCF

12 (100)

Tumor number at inclusion^c

1

7 (58)

2

1 (8)

3

4 (33)

Longest tumor diameter at baseline^d (cm)

mRECIST median

2.5

[1.5–4.4]

Total diameter at baseline^d (cm)

mRECIST median

2.6

[1.8–6.3]

 Longest diameter (cm)

Median

4.3

[0.8–6.5]

 Total diameter (cm)

Median

5.0

[1.3–12.2]

 Tumor number

1/2/3/> 3

5/3/1/3

 Vascular invasion

Macro/Micro/None/undef

1/7/3/1

 Differentiation grade (Edmonson)

2/3/4/undef

2/8/1/1

 Mixed type HCC

Cholangiocellular diff

1 (8)