Prognostic significance of serum aspartic transaminase in diffuse large B-cell lymphoma

BMC Cancer

Table 3 Relationships between clinical features and ALT and AST status

Characteristics	ALT⁺	ALT⁻	P value	AST⁺	AST⁻	P value
Characteristics	No. of cases		P value	No. of cases		P value
Age (years)
≤60	16	85	0.100	27	74	0.447
> 60	6	72	0.100	17	61	0.447
Sex
Male	16	88	0.138	24	80	0.582
Female	6	69	0.138	20	55	0.582
Stage
III-IV	12	87	0.939	34	65	0.001
I-II	10	70	0.939	10	70	0.001
ECOG PS
≥ 2	6	22	0.121	12	16	0.014
< 2	16	135	0.121	32	119	0.014
LDH
Over ULN	13	59	0.054	36	36	< 0.0001
Normal	9	98	0.054	8	99	< 0.0001
ENI
≥ 2	5	38	0.250	16	27	0.027
< 2	17	119	0.250	28	108	0.027
IPI
3–5	7	45	0.760	21	31	0.002
0–2	15	112	0.760	23	104	0.002
B symptoms
Positive	11	51	0.106	24	38	0.001
Negative	11	106	0.106	20	97	0.001
COO (Hans)
GCB	6	71	0.111	13	64	0.038
Non-GCB	16	86	0.111	31	71	0.038

Abbreviations: ALT alanine aminotransferase, AST aspartate aminotransferase, COO cell of origin, ECOG PS performance status of Eastern Cooperative Oncology Group, ENI extra nodal involvement, GCB germinal-center B-cell type, LDH lactate dehydrogenase, IPI International Prognostic Index

ISSN: 1471-2407