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Table 4 Overall survival and progression-free survival according to immunohistochemical staining of VEGFs and receptors and clinical characteristics

From: Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Variable

Univariate analysis

Multivariate analysis

Hazard ratio,

95%Cl

p

Overall survival

VEGF-A IRS

0.024

   

VEGF-A PP (serous tumors)

0.005

   

VEGF-A SI stroma

0.003

   

Stage

< 0.001

   

Ascites

0.046

   

Primary residual tumor

 None

    

  < 1 cm

< 0.001

4.208

1.832–9.664

0.001

  > 1 cm

< 0.001

4.392

2.159–8.938

< 0.001

Chemotherapy response

 Complete response

    

 Partial response

< 0.001

3.75

1.318–10.665

0.013

 Stable disease

< 0.001

23.768

4.33–130.45

< 0.001

 Progressive disease

< 0.001

12.896

4.67–35.612

< 0.001

Progression-free survival

 VEGF-C PP (serous tumors)

0.034

   

 VEGF-C SI stroma

0.036

0.131

0.021–0.815

0.029

 VEGFR3 SI

0.002

   

 Stage

< 0.001

0.02

0.001–0.32

0.022

 Ascites

0.028

2.152

1.018–4.55

0.045

  1. IRS immunoreactive score, PP percentage of positively stained epithelial cells, SI staining intensity
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BMC Cancer

ISSN: 1471-2407

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