Table 4 Frequency of Variants of Uncertain Significance (VUS) among tested individuals
Individuals | % VUS rate | % VUS rate | |||
|---|---|---|---|---|---|
BRCA1 and BRCA2 | Other high-risk genes | Genes with moderate risk | Genes with low/unknown risk | ||
Total individuals | 34.8% (417/1197) | 3.0% (36/1197) | 15.5% (185/1197) | 13.0% (156/1197) | 10.1% (121/1197) |
 Greek | 35.5% (224/631) | 2.2% (14/631) | 16.2% (102/631) | 13.8% (87/631) | 10.9% (69/631) |
 Romanian | 30.4% (124/408) | 2.5% (10/408) | 13.2% (54/408) | 11.3% (46/408) | 9.3% (38/408) |
 Turkish | 43.7% (69/158) | 7.6% (12/158) | 18.4% (29/158) | 14.6% (23/158) | 8.9% (14/158) |
Affected individuals | 34.8% (323/929) | 2.8% (26/929) | 15.6% (145/929) | 12.3% (114/929) | 10.3% (96/929) |
 Breast cancer | 34.9% (268/768) | 2.6% (20/768) | 15.2% (117/768) | 10.7% (82/768) | 6.4% (49/768) |
 Colorectal cancer | 36.8% (25/68) | 2.9% (2/68) | 13.2% (9/68) | 8.8% (6/68) | 11.8% (8/68) |
 Ovarian cancer | 31.0% (13/42) | 4.8% (2/42) | 16.7% (7/42) | 4.8% (2/42) | 4.8% (2/42) |
 Other cancers | 41.0% (25/61) | 3.3% (2/61) | 24.6% (15/61) | 8.2% (5/61) | 4.9% (3/61) |
Unaffected individuals | 39.0% (55/141) | 2.8% (4/141) | 16.3% (23/141) | 19.1% (27/141) | 9.2% (13/141) |
 FH of Breast cancer | 41.7% (43/103) | 2.9% (3/103) | 15.5% (16/103) | 22.3% (23/103) | 9.7% (10/103) |
 FH of Colorectal cancer | 31.3% (10/32) | 3.1% (1/32) | 15.6% (5/32) | 12.5% (4/32) | 6.3% (2/32) |
 FH of Ovarian cancer | 36.7% (11/30) | 0.0% (0/30) | 10.0% (3/30) | 20.0% (6/30) | 10.0% (3/30) |
Individuals with no information | 30.7% (39/127) | 4.7% (6/127) | 13.4% (17/127) | 11.8% (15/127) | 13.4% (17/127) |