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Table 4 Frequency of Variants of Uncertain Significance (VUS) among tested individuals

From: Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations

Individuals % VUS rate % VUS rate
BRCA1 and BRCA2 Other high-risk genes Genes with moderate risk Genes with low/unknown risk
Total individuals 34.8% (417/1197) 3.0% (36/1197) 15.5% (185/1197) 13.0% (156/1197) 10.1% (121/1197)
 Greek 35.5% (224/631) 2.2% (14/631) 16.2% (102/631) 13.8% (87/631) 10.9% (69/631)
 Romanian 30.4% (124/408) 2.5% (10/408) 13.2% (54/408) 11.3% (46/408) 9.3% (38/408)
 Turkish 43.7% (69/158) 7.6% (12/158) 18.4% (29/158) 14.6% (23/158) 8.9% (14/158)
Affected individuals 34.8% (323/929) 2.8% (26/929) 15.6% (145/929) 12.3% (114/929) 10.3% (96/929)
 Breast cancer 34.9% (268/768) 2.6% (20/768) 15.2% (117/768) 10.7% (82/768) 6.4% (49/768)
 Colorectal cancer 36.8% (25/68) 2.9% (2/68) 13.2% (9/68) 8.8% (6/68) 11.8% (8/68)
 Ovarian cancer 31.0% (13/42) 4.8% (2/42) 16.7% (7/42) 4.8% (2/42) 4.8% (2/42)
 Other cancers 41.0% (25/61) 3.3% (2/61) 24.6% (15/61) 8.2% (5/61) 4.9% (3/61)
Unaffected individuals 39.0% (55/141) 2.8% (4/141) 16.3% (23/141) 19.1% (27/141) 9.2% (13/141)
 FH of Breast cancer 41.7% (43/103) 2.9% (3/103) 15.5% (16/103) 22.3% (23/103) 9.7% (10/103)
 FH of Colorectal cancer 31.3% (10/32) 3.1% (1/32) 15.6% (5/32) 12.5% (4/32) 6.3% (2/32)
 FH of Ovarian cancer 36.7% (11/30) 0.0% (0/30) 10.0% (3/30) 20.0% (6/30) 10.0% (3/30)
Individuals with no information 30.7% (39/127) 4.7% (6/127) 13.4% (17/127) 11.8% (15/127) 13.4% (17/127)