Table 1 List of Genes analyzed by the Hereditary Cancer panels and their association with various cancer types and syndromes

 APC

NM_000038.5

***

*

*

*

*

Familiar Adenomatus Polyposis (FAP)

 BMPR1A

NM_004329.2

***

**

*

Juvenile Polyposis Syndrome (JPS)

 BRCA1

NM_007294.2

***

***

*

**

*

Hereditary Breast and Ovarian Cancer Syndrome (HBOC)

 BRCA2

NM_000059.3

***

**

*

*

**

*

Hereditary Breast and Ovarian Cancer Syndrome (HBOC)

 CDH1

NM_004360.4

***

***

Hereditary Diffuse Gastric Cancer (HDGC)

 CDK4

NM_000075.3

***

 CDKN2A

NM_000077.4

***

*

Familial Atypical Multiple Mole Melanoma Syndrome,

Melanoma-Pancreatic Cancer Syndrome

 EPCAM

NM_002354.2

*

*

***

**

*

*

*

*

Lynch Syndrome (LS)

 MEN1

NM_000244.3

*

***

Multiple Endocrine Neoplasia Type 1

 MLH1

NM_000249.3

*

**

***

**

*

*

*

Lynch Syndrome (LS)

 MSH2

NM_000251.2

*

**

***

**

*

*

*

Lynch Syndrome (LS)

 MSH6

NM_000179.2

*

*

***

***

*

*

*

Lynch Syndrome (LS)

 MUTYH

NM_001128425.1

*

***

*

*

*

MUTYH-associated polyposis (MAP)

 PALB2

NM_024675.3

***

*

*

*

Fanconi anemia (FA-N) (recessive)

 PMS2

NM_000535.5

*

***

***

*

*

*

*

Lynch Syndrome (LS)

 PTEN

NM_000314.4

***

*

*

*

**

**

Cowden Syndrome (CS)

 RET

NM_020975.4

***

Multiple Endocrine Neoplasia Type 2

 SMAD4

NM_005359.5

***

**

Juvenile Polyposis Syndrome (JPS)

 STK11

NM_000455.4

***

*

**

*

**

**

Peutz–Jeghers Syndrome (PJS)

 TP53

NM_000546.5

***

*

**

*

*

**

**

*

Li–Fraumeni Syndrome (LFS)

 VHL

NM_000551.3

*

*

***

Von Hippel-Lindau Syndrome

 ATM

NM_000051.3

**

*

*

Ataxia-Telangiectasia (recessive)

 BRIP1

NM_032043.2

*

**

*

Fanconi anemia (FA-J) (recessive)

 CHEK2

NM_007194.3

**

*

*

*

 NBN

NM_002485.4

**

*

Nijmegen Breakage Syndrome (NBS)

 RAD51C

NM_058216.2

*

**

Fanconi anemia (FA-O) (recessive)

 RAD51D

NM_002878.3

*

**

Fanconi anemia (FA) (recessive)

 BARD1

NM_000465.2

*

*

 BLM

NM_000057.2

*

*

Bloom Syndrome (BS)

 CHEK1

NM_001114121.2

*

 ABRAXAS1 (FAM175A)

NM_139076.2

*

 MRE11 (MRE11A)

NM_005591.3

*

Ataxia-Telangiectasia-like disorder

 NF1

NM_000267.3

*

*

*

Neurofibromatosis type 1

 RAD50

NM_005732.3

*

Nijmegen breakage syndrome-like disorder (NBSLD)

 RAD51B

NM_133509.3

*

 XRCC2

NM_005431.1

*