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Table 2 Univariate and multivariate survival analyses for overall survival in ESCC patients

From: Clinical use of tumor biomarkers in prediction for prognosis and chemotherapeutic effect in esophageal squamous cell carcinoma

Variable Overall survival
Univariate Multivariate
HR (95% CI) p HR (95% CI) p
Age(y)   0.362   
  < 60 1    
  ≥ 60 1.127 (0.871–1.459)    
Gender   0.011   0.010
 Male 1   1  
 Female 0.630 (0.441–0.898)   0.624 (0.435–0.894)  
Tumor length (cm)   < 0.001   0.257
  < 4 1   1  
  ≥ 4 1.665 (1.266–2.190)   1.182 (0.885–1.579)  
Tumor location   0.772   
 Upper 1    
 Middle 1.085 (0.672–1.752)    
 Lower 0.983 (0.594–1.627)    
Differentiation   0.982   
 Well - moderate 1    
 Poor 1.004 (0.725–1.390)    
pT category   < 0.001   < 0.001
 T1 1   1  
 T2 2.000 (0.786–5.090)   1.893 (0.739–4.847)  
 T3 3.456 (1.365–8.747)   3.017 (1.171–7.772)  
 T4 5.604 (2.297–13.671)   4.674 (1.887–11.577)  
pN category   < 0.001   < 0.001
 pN0 1   1  
 pN1 2.469 (1.856–3.286)   2.331 (1.732–3.316)  
 pN2 2.801 (1.805–4.347)   2.949 (1.840–4.725)  
 pN3 3.487 (2.015–6.035)   3.461 (1.960–6.109)  
TNM stage   < 0.001   
 I 1    
 II 1.974 (0.709–5.500)    
 III 6.010 (2.231–16.192)    
Postoperative chemotherapy   0.015   < 0.001
 Yes 1   1  
 No 1.376 (1.063–1.780)   1.935 (1.468–2.549)  
CA19–9   0.001   0.018
  < 37 1   1  
  ≥ 37 2.754 (1.535–4.938)   2.130 (1.138–3.986)  
CA72–4   0.799   
  < 6 1    
  ≥ 6 0.942 (0.596–1.490)    
CEA   < 0.001   0.022
  < 5 1   1  
  ≥ 5 3.512 (2.159–5.713)   1.827 (1.089–3.064)  
Cyfra21–1   0.018   0.166
  < 3.4 1   1  
  ≥ 3.4 1.409 (1.061–1.871)   1.238 (0.915–1.676)  
SCC-Ag   0.010   0.631
  < 1.5 1   1  
  ≥ 1.5 1.472 (1.096–1.975)   0.926 (0.677–1.267)  
  1. Abbreviations: CA carbohydrate antigen, CEA carcinoembryonic antigen, CI confidence interval, ESCC esophageal squamous cell carcinoma, HR hazard ratio, SCC-Ag squamous cell carcinoma antigen