Table 2 Univariate and multivariate survival analyses for overall survival in ESCC patients

Age(y)

0.362

  < 60

1

  ≥ 60

1.127 (0.871–1.459)

Gender

0.011

0.010

 Male

1

1

 Female

0.630 (0.441–0.898)

0.624 (0.435–0.894)

Tumor length (cm)

< 0.001

0.257

  < 4

1

1

  ≥ 4

1.665 (1.266–2.190)

1.182 (0.885–1.579)

Tumor location

0.772

 Upper

1

 Middle

1.085 (0.672–1.752)

 Lower

0.983 (0.594–1.627)

Differentiation

0.982

 Well - moderate

1

 Poor

1.004 (0.725–1.390)

pT category

< 0.001

< 0.001

 T1

1

1

 T2

2.000 (0.786–5.090)

1.893 (0.739–4.847)

 T3

3.456 (1.365–8.747)

3.017 (1.171–7.772)

 T4

5.604 (2.297–13.671)

4.674 (1.887–11.577)

pN category

< 0.001

< 0.001

 pN0

1

1

 pN1

2.469 (1.856–3.286)

2.331 (1.732–3.316)

 pN2

2.801 (1.805–4.347)

2.949 (1.840–4.725)

 pN3

3.487 (2.015–6.035)

3.461 (1.960–6.109)

TNM stage

< 0.001

 I

1

 II

1.974 (0.709–5.500)

 III

6.010 (2.231–16.192)

Postoperative chemotherapy

0.015

< 0.001

 Yes

1

1

 No

1.376 (1.063–1.780)

1.935 (1.468–2.549)

CA19–9

0.001

0.018

  < 37

1

1

  ≥ 37

2.754 (1.535–4.938)

2.130 (1.138–3.986)

CA72–4

0.799

  < 6

1

  ≥ 6

0.942 (0.596–1.490)

CEA

< 0.001

0.022

  < 5

1

1

  ≥ 5

3.512 (2.159–5.713)

1.827 (1.089–3.064)

Cyfra21–1

0.018

0.166

  < 3.4

1

1

  ≥ 3.4

1.409 (1.061–1.871)

1.238 (0.915–1.676)

SCC-Ag

0.010

0.631

  < 1.5

1

1

  ≥ 1.5

1.472 (1.096–1.975)

0.926 (0.677–1.267)